General
Preferred name
L-741,626
Synonyms
4-(4-Chloro-phenyl)-1-(1H-indol-3-ylmethyl)-piperidin-4-ol ()
L-741626 ()
P&D ID
PD015057
CAS
81226-60-0
Tags
drug candidate
natural product
available
Drug indication
Discovery agent
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Selective D2 dopamine receptor antagonist (LOPAC library)
DESCRIPTION Highly selective D4 antagonist (Tocris Bioactive Compound Library)
DESCRIPTION L-741,626 is a selective and potent D2 dopamine receptor antagonist. It is centrally active following systemic administration in vivo. It inhibits quinpirole-stimulated mitogenesis transfected with human D2 and D3 receptors in a functional assay. It reversibly blocks D2-mediated currents in Xenopus oocytes by G protein-gated inwardly rectifying K+ (GIRK) channels. It inhibits the conditioned avoidance response (CAR) in rats and apomorphine-induced climbing behavior in mice. It evokes a catalepsy response and blocks gnawing induced by methylphenidate in rat models of potential extrapyramidal activity. (BOC Sciences Bioactive Compounds)
Cell lines
0
Organisms
1
Compound Sets
17
AdooQ Bioactive Compound Library
A13694
BOC Sciences Bioactive Compounds
l-741-626-cas-81226-60-0-item-302110
Cayman Chemical Bioactives
22354
Concise Guide to Pharmacology 2017/18
177
Concise Guide to Pharmacology 2019/20
177
Concise Guide to Pharmacology 2021/22
177
Concise Guide to Pharmacology 2023/24
177
DrugMAP
DMCYQJF
DrugMatrix
EUbOPEN Chemogenomics Library
Guide to Pharmacology
177
Ki Database
4-(4-Chloro-phenyl)-1-(1H-indol-3-ylmethyl)-piperidin-4-ol
LOPAC library
Mcule NIBR MoA Box Subset
MCULE-7995048586
MedChem Express Bioactive Compound Library
HY-101348
Novartis Chemogenetic Library (NIBR MoA Box)
Tocris Bioactive Compound Library
1003
External IDs
20
Properties
(calculated by RDKit )
Molecular Weight
340.13
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
2
Rotatable Bonds
3
Ring Count
4
Aromatic Ring Count
3
cLogP
4.3
TPSA
39.26
Fraction CSP3
0.3
Chiral centers
0.0
Largest ring
6.0
QED
0.75
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Selectivity
D2
Primary Target
D2 Receptors
MOA
Antagonist
Dopamine D2 Antagonists
Member status
member
Pathway
GPCR/G protein
Neuronal Signaling
Target
Dopamine Receptor
Source data