General
Preferred name
TYRPHOSTIN B48
Synonyms
Tyrphostin AG 494 ()
AG 494 ()
Tyrphostin AG-494 ()
AG-494 ()
P&D ID
PD015005
CAS
133550-35-3
139087-53-9
Tags
available
drug candidate
Drug Status
experimental
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION AG-494 (Tyrphostin AG 494) is a potent and selective EGFR tyrosine kinase inhibitor (IC50=0.7 ¦ÌM). AG-494 inhibits the autophosphorylation of EGFR, ErbB2, HER1-2 and PDGF-R with IC50s 1.1, 39, 45 and 6 ¦ÌM, respectively. AG-494 blocks Cdk2 activation and inhibits EGF-dependent DNA synthesis[1][2][3].
PRICE 30
DESCRIPTION Protein tyrosine kinase inhibitor. Inhibits EGF-receptor kinase activity. (LOPAC library)
DESCRIPTION Potent EGFR-kinase inhibitor (Tocriscreen Total)
DESCRIPTION AG-494 (Tyrphostin B48) is an inhibitor of epidermal growth factor receptor kinase. (TargetMol Bioactive Compound Library)
Compound Sets
8
Cayman Chemical Bioactives
10010242
Drug Repurposing Hub
DrugBank
DB16774
LOPAC library
MedChem Express Bioactive Compound Library
HY-101042
Selleckchem Bioactive Compound Library
ag-494
TargetMol Bioactive Compound Library
T4205
Tocriscreen Total
External IDs
21
Properties
(calculated by RDKit )
Molecular Weight
280.08
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
3
Rotatable Bonds
3
Ring Count
2
Aromatic Ring Count
2
cLogP
2.64
TPSA
93.35
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
6.0
QED
0.46
QED
0.46
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
EGFR
Target
CDK
MOA
EGFR inhibitor
Pathway
Cell Cycle/DNA Damage
JAK/STAT Signaling
Protein Tyrosine Kinase/RTK
Angiogenesis
Cell Cycle/Checkpoint
Tyrosine Kinase/Adaptors
Source data