General
Preferred name
TETRADECYLTHIOACETIC ACID
Synonyms
TTA ()
2-(Tetradecylthio)acetic acid ()
Tetradcylthioacetic acid ()
Tetradecylsulfanyl-Acetic Acid ()
P&D ID
PD014999
CAS
2921-20-2
Tags
available
drug candidate
Drug Status
investigational
Max Phase
2.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE
42
DESCRIPTION
Tetradecylthioacetic acid is a synthetic fatty acid with a sulfur substitution in the ??-position. This modification renders TTA unable to undergo complete ??-oxidation and increases its biological activity, including activation of peroxisome proliferator activated receptors (PPARs) with preference for PPAR??.
DESCRIPTION
Peroxisome proliferator-activated receptor (PPAR)-alpha agonist
(LOPAC library)
DESCRIPTION
Tetradecylthioacetic acid is a synthetic fatty acid with a sulfur substitution in the β-position. This modification renders TTA unable to undergo complete β-oxidation and increases its biological activity, including activation of peroxisome proliferator activated receptors (PPARs) with preference for PPARα.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
9
ChEMBL Drugs
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
LOPAC library
MedChem Express Bioactive Compound Library
NURSA ligand set
ReFrame library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
29
Molecular Weight
288.21
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
1
Rotatable Bonds
15
Ring Count
0
Aromatic Ring Count
0
cLogP
5.51
TPSA
37.3
Fraction CSP3
0.94
Chiral centers
0.0
Largest ring
0.0
QED
0.4
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
PPAR-alpha
Target
PPAR
MOA
lipid peroxidase inhibitor
Pathway
DNA Damage/DNA Repair
Metabolism
Cell Cycle/DNA Damage
Metabolic Enzyme/Protease
Vitamin D Related/Nuclear Receptor
Source data
