General
Preferred name
SB 206553 hydrochloride
Synonyms
SB206553 hydrochloride ()
SB 206553 (hydrochloride) ()
SB-206553 (hydrochloride) ()
P&D ID
PD014994
CAS
1197334-04-5
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION SB 206553 hydrochloride is a high affinity, selective and orally active 5-HT2B / 5-HT2C receptor antagonist (rat 5-HT2B pA2 = 8.89, human 5-HT2C pKi = 7.92)[1]. SB 206553 possesses anxiolytic-like properties[2].
PRICE 241
DESCRIPTION Potent 5-HT2C/5-HT2B serotonin receptor antagonist (LOPAC library)
DESCRIPTION SB 206553 hydrochloride is a potent and selective 5-HT2B/5-HT2C receptor antagonist (rat 5-HT2B pA2 = 8.89, human 5-HT2C pKi = 7.92) with > 80-fold selectivity over all other 5-HT receptor subtypes and a variety of other receptors (pKi < 6). (BOC Sciences Bioactive Compounds)
DESCRIPTION Potent, selective 5-HT2C/5-HT2B antagonist. Orally active (Tocriscreen Plus)
DESCRIPTION Potent, selective 5-HT2C/5-HT2B antagonist. Orally active (Tocriscreen Total)
DESCRIPTION SB 206553 hydrochloride is an orally active, selective, and efficient 5-HT2C inverse agonist and 5-HT2C/5-HT2B receptor antagonist with anti-anxiety activity. It is useful in neurological disease research. (TargetMol Bioactive Compound Library)
DESCRIPTION Selective D1-like partial agonist (Tocris Bioactive Compound Library)
Cell lines
0
Organisms
1
Compound Sets
8
BOC Sciences Bioactive Compounds
sb-206553-hydrochloride-cas-1197334-04-5-item-170620
Cayman Chemical Bioactives
34263
LOPAC library
MedChem Express Bioactive Compound Library
HY-103135
TargetMol Bioactive Compound Library
T23314
Tocris Bioactive Compound Library
1661
Tocriscreen Plus
1661
Tocriscreen Total
External IDs
10
Properties
(calculated by RDKit )
Molecular Weight
328.11
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
1
Rotatable Bonds
1
Ring Count
4
Aromatic Ring Count
3
cLogP
3.59
TPSA
50.16
Fraction CSP3
0.18
Chiral centers
0.0
Largest ring
6.0
QED
0.74
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
7-TM Receptors
Selectivity
5-HT2C/5-HT2B
Target
HIV
5-HT Receptor
Primary Target
5-HT2C Receptors
MOA
Antagonist
Pathway
GPCR/G protein
Neuronal Signaling
Microbiology/virology
Proteases/Proteasome
Source data