General
Preferred name
GALLOPAMIL HYDROCHLORIDE
Synonyms
(±)-Methoxyverapamil hydrochloride ()
D600 ()
METHOXYVERAPAMIL HYDROCHLORIDE ()
Gallopamil (hydrochloride) ()
Methoxyverapamil (hydrochloride) ()
GALLOPAMIL ()
P&D ID
PD014958
CAS
56949-75-8
16662-46-7
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Gallopamil hydrochloride (Methoxyverapamil hydrochloride), a methoxy derivative of Verapamil, is a phenylalkylamine calcium antagonist[1]. Gallopamil hydrochloride inhibits acid secretion in a concentration-dependent manner with an IC50 of 10.9 ¦ÌM[2]. Gallopamil hydrochloride is a potent antiarrhythmic and vasodilator agent[3].
PRICE 93
DESCRIPTION L-type Ca2+ channel antagonist (LOPAC library)
DESCRIPTION (±)-Methoxyverapamil is a phenylalkylamine L-type calcium channel blocker and methoxy derivative of verapamil. (±)-Methoxyverapamil blocks recombinant rat L-type calcium channels expressed in tsA201 cells with IC50 values of 782 and 8,000 nM at holding potentials of 10 and -60 mV, respectively. (BOC Sciences Bioactive Compounds)
DESCRIPTION Gallopamil hydrochloride (Methoxyverapamil hydrochloride) is an antagonist of phenylalkylamine calcium. Gallopamil hydrochloride can be used in antiarrhythmic and vasodilator studies. (TargetMol Bioactive Compound Library)
Cell lines
0
Organisms
1
Compound Sets
6
BOC Sciences Bioactive Compounds
3-cyano-3-3-4-5-trimethoxyphenyl-hex-6-yl-5-6-dimethoxyphenethyl-cas-16662-46-7-item-60526
EUbOPEN Chemogenomics Library
EUB0001923
Ki Database
D600
LOPAC library
MedChem Express Bioactive Compound Library
HY-14276A
TargetMol Bioactive Compound Library
T11353L
External IDs
19
Properties
(calculated by RDKit )
Molecular Weight
520.27
Hydrogen Bond Acceptors
7
Hydrogen Bond Donors
0
Rotatable Bonds
14
Ring Count
2
Aromatic Ring Count
2
cLogP
5.52
TPSA
73.18
Fraction CSP3
0.54
Chiral centers
1.0
Largest ring
6.0
QED
0.32
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
L-type
Target
Ca(2+) receptor
Calcium Channel
Pathway
Membrane Transporter/Ion Channel
Neuronal Signaling
Metabolism
Recommended Cell Concentration
1 uM
Source data