General
Preferred name
(±)-Methoxyverapamil hydrochloride
Synonyms
D600 ()
Gallopamil (hydrochloride) ()
Methoxyverapamil (hydrochloride) ()
(+/-)-Methoxyverapamil HCl ()
METHOXYVERAPAMIL HYDROCHLORIDE ()
P&D ID
PD014958
CAS
56949-75-8
16662-46-7
Tags
natural product
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION L-type Ca2+ channel antagonist (LOPAC library)
DESCRIPTION (±)-Methoxyverapamil is a phenylalkylamine L-type calcium channel blocker and methoxy derivative of verapamil. (±)-Methoxyverapamil blocks recombinant rat L-type calcium channels expressed in tsA201 cells with IC50 values of 782 and 8,000 nM at holding potentials of 10 and -60 mV, respectively. (BOC Sciences Bioactive Compounds)
Cell lines
0
Organisms
1
Compound Sets
4
BOC Sciences Bioactive Compounds
3-cyano-3-3-4-5-trimethoxyphenyl-hex-6-yl-5-6-dimethoxyphenethyl-cas-16662-46-7-item-60526
Ki Database
D600
LOPAC library
MedChem Express Bioactive Compound Library
HY-14276A
External IDs
18
Properties
(calculated by RDKit )
Molecular Weight
520.27
Hydrogen Bond Acceptors
7
Hydrogen Bond Donors
0
Rotatable Bonds
14
Ring Count
2
Aromatic Ring Count
2
cLogP
5.52
TPSA
73.18
Fraction CSP3
0.54
Chiral centers
1.0
Largest ring
6.0
QED
0.32
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
L-type
Pathway
Membrane Transporter/Ion Channel
Neuronal Signaling
Target
Calcium Channel
Source data