General
Preferred name
ML 10302
Synonyms
ML10302 ()
ML 10302 hydrochloride ()
ML-10302 ()
P&D ID
PD014947
CAS
148868-55-7
186826-17-5
Tags
available
drug candidate
Drug indication
Discovery agent
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE
63
DESCRIPTION
ML 10302 is a potent agonist 5-HT4 receptor with Ki of 1.07 nM. 5-Hydroxytryptamine (5-HT4) receptor agonists stimulate gut motility through cholinergic pathways. ML10302 induces significant prokinesia both in the small bowel and colon through activation of cholinergic pathways. ML 10302 also has the potential for the research of neurology diseases[1].
DESCRIPTION
Potent and selective 5-HT4 partial agonist
(Tocriscreen Plus)
DESCRIPTION
ML 10302 hydrochloride is a 5-HT4 agonist with EC50 value of 4 nM. It can increase sAPPĪ± levels in the cortex in an animal model of Alzheimer's disease and exhibit progastrokinetic effects in vivo.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
ML 10302 hydrochloride is a specific agonist 5-HT4 and binds 5-HT receptors with Kis of 1.07 nM and 782 nM for 5-HT4 and 5-HT3.
(TargetMol Bioactive Compound Library)
DESCRIPTION
Potent, selective 5-HT4 serotonin receptor agonist.
(LOPAC library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
2
Compound Sets
15
BOC Sciences Bioactive Compounds
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugMAP
DrugMatrix
Guide to Pharmacology
Ki Database
LOPAC library
MedChem Express Bioactive Compound Library
TargetMol Bioactive Compound Library
Tocriscreen Plus
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
25
Molecular Weight
312.12
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
1
Rotatable Bonds
5
Ring Count
2
Aromatic Ring Count
1
cLogP
2.57
TPSA
64.79
Fraction CSP3
0.53
Chiral centers
0.0
Largest ring
6.0
QED
0.67
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
7-TM Receptors
Selectivity
5-HT4
Target
HTR3A, HTR3B, HTR4
5-HT Receptor
MOA
serotonin receptor partial agonist
Pathway
GPCR/G protein
Neuronal Signaling
Neuroscience
Source data
