General
Preferred name
NF 023
Synonyms
NF023 ()
NF023 (hexasodium) ()
P&D ID
PD014939
CAS
104869-31-0
Tags
available
drug candidate
Drug indication
Discovery agent
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Potent, selective P2X1 receptor antagonist
(LOPAC library)
DESCRIPTION
Potent competitive NMDA antagonist
(Tocris Bioactive Compound Library)
DESCRIPTION
NF 023 is a subtype-selective P2X1 receptor antagonist with IC50 value of 0.21μM for human P2X1.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
11
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
DrugMAP
Guide to Pharmacology
LOPAC library
MedChem Express Bioactive Compound Library
Tocris Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
16
Properties
(calculated by RDKit )
Molecular Weight
1161.83
Hydrogen Bond Acceptors
21
Hydrogen Bond Donors
4
Rotatable Bonds
12
Ring Count
6
Aromatic Ring Count
6
cLogP
-16.41
TPSA
442.53
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
6.0
QED
0.07
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Selectivity
P2X1
Primary Target
Purinergic (P2X) Receptors
MOA
Antagonist
Pathway
Membrane Transporter/Ion Channel
Target
P2X Receptor
Source data