General
Preferred name
Oleic monoethanolamide
Synonyms
N-Oleoylethanolamine ()
Oleylethanolamide ()
N-Oleoyl-2-aminoethanol ()
Oleic acid monoethanolamide ()
Oleamide MEA ()
N-oleoylethanolamide ()
OLEOYLETHANOLAMIDE ()
Oleoyl Ethanolamide ()
Oleoyl Ethanolamide-d4 ()
Oleoyl Ethanolamide-d2 ()
P&D ID
PD014920
CAS
111-58-0
946524-36-3
1245477-09-1
Tags
available
drug candidate
Drug indication
Discovery agent
Drug Status
investigational
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Oleoylethanolamide is a high affinity endogenous PPAR-¦Á agonist, which plays an important role in the treatment of obesity and arteriosclerosis.
PRICE
55
DESCRIPTION
Oleoylethanolamide (N-Oleoylethanolamide) is a high affinity endogenous agonist of PPAR-??.
DESCRIPTION
Selective Hsp90 inhibitor
(Tocris Bioactive Compound Library)
DESCRIPTION
Ceramidase inhibitor; inhibits sphingolipid signaling pathway
(LOPAC library)
DESCRIPTION
GPR55 agonist. Also PPARα agonist
(Tocriscreen Total)
DESCRIPTION
Oleylethanolamide is an endogenous agonist for PPARα with an EC50 value of 120 nM in a transactivation assay. Oleylethanolamide is also a selective GPR55 agonist with EC50 value of 120 μM. It is involved in peripheral regulation of feeding.
Nutritional supplement in health care products. (BOC Sciences Bioactive Compounds)
Nutritional supplement in health care products. (BOC Sciences Bioactive Compounds)
DESCRIPTION
Oleoylethanolamide (N-Oleoylethanolamide) is a high affinity endogenous agonist of PPAR-α.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
1
Organisms
2
Compound Sets
19
BOC Sciences Bioactive Compounds
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
Drug Repurposing Hub
DrugBank
DrugMAP
EU-OPENSCREEN Bioactive Compound Library
EUbOPEN Chemogenomics Library
Guide to Pharmacology
LOPAC library
MedChem Express Bioactive Compound Library
Novartis Chemogenetic Library (NIBR MoA Box)
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
Tocris Bioactive Compound Library
Tocriscreen Total
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
44
Molecular Weight
325.3
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
2
Rotatable Bonds
17
Ring Count
0
Aromatic Ring Count
0
cLogP
5.13
TPSA
49.33
Fraction CSP3
0.85
Chiral centers
0.0
Largest ring
0.0
QED
0.29
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
Ceramidase
Target
Endogenous Metabolite
Human Endogenous Metabolite
PPAR
PPARα
CNR1, GPR119, GPR55, PPARA
Primary Target
Other Lipid Metabolism
Member status
member
MOA
Glucose-Dependent Insulinotropic Receptor (GDIR, GPR119) Agonists
K(V)4.3 Channel Blockers
cannabinoid receptor agonist, glucose dependent insulinotropic receptor agonist, potassium channel blocker, PPAR receptor agonist
Pathway
DNA Damage/DNA Repair
Metabolism
Cell Cycle/DNA Damage
Metabolic Enzyme/Protease
Vitamin D Related/Nuclear Receptor
Solubility
water, 0.06886 mg/L @ 25 °C (est)
Recommended Cell Concentration
1 uM
Source data
