General
Preferred name
pecazine
Synonyms
MEPAZINE ()
MEPAZINE ACETATE ()
Pecazine hydrochloride ()
Mepazine Hydrochloride ()
Mepazine (hydrochloride) ()
Pecazine (hydrochloride) ()
Mesapin ()
Pakatal ()
P-391 ()
Pecazina ()
Mepazine base ()
Pacatal base ()
Pacatol ()
Meprazine ()
Pacatal ()
III-2318 ()
Nothiazine ()
Mepazin ()
Mepasin ()
Lacumin ()
Paxital ()
Pecatal ()
NND 1964 ()
Pecazine acetate ()
P&D ID
PD014813
CAS
60-89-9
24360-97-2
2975-36-2
Tags
available
drug
Drug Status
approved
withdrawn
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Pecazine is a phenothiazine derivative that was historically used as an antipsychotic/tranquillizer, but use has replaced by newer drugs. Pecazine is also an allosteric inhibitor of MALT1 protease activity , and a RANKL inhibitor. It may be used experimentally as the acetate or hydrochloride. (GtoPdb)
DESCRIPTION Mepazine (Pecazine) is a potent and selective MALT1 protease inhibitor with IC50s of 0.83 and 0.42 ¦ÌM for GSTMALT1 full length and GSTMALT1 325-760, respectively. Mepazine affects viability of ABC-DLBCL cells by enhancing apoptosis[1].
PRICE 29
DESCRIPTION Mepazine (Pecazine) is a potent and selective inhibitor of MALT1, inhibiting GSTMALT1 full length and GSTMALT1 325-760 with IC50s of 0.83 ??M and 0.42 ??M, respectively. Mepazine enhances apoptosis and impacts cell viability.
DESCRIPTION Mepazine hydrochloride (Pecazine hydrochloride) is a potent and selective MALT1 protease inhibitor with IC50s of 0.83 and 0.42 ¦ÌM for GSTMALT1 full length and GSTMALT1 325-760, respectively. Mepazine hydrochloride affects viability of ABC-DLBCL cells by enhancing apoptosis[1].
PRICE 45
DESCRIPTION Mepazine (Pecazine) is a potent and selective inhibitor of MALT1, inhibiting GSTMALT1 full length and GSTMALT1 325-760 with IC50s of 0.83 μM and 0.42 μM, respectively. Mepazine enhances apoptosis and impacts cell viability. (TargetMol Bioactive Compound Library)
DESCRIPTION Mepazine hydrochloride (Pecazine hydrochloride) is a potent MALT1 inhibitor with anticancer and antitumor activities. Mepazine hydrochloride inhibits RANK-induced osteoclastogenesis, suppresses MALT1 activity and tumor growth in pancreatic cancer. (TargetMol Bioactive Compound Library)
Compound Sets
12
ChEMBL Approved Drugs
CHEMBL395110
CHEMBL1712842
ChEMBL Drugs
CHEMBL395110
CHEMBL1712842
DrugCentral
1688
DrugCentral Approved Drugs
1688
DrugMatrix
Guide to Pharmacology
9782
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL395110
CHEMBL1712842
MedChem Express Bioactive Compound Library
HY-121282
HY-121282A
NPC Screening Collection
ReFrame library
TargetMol Bioactive Compound Library
T16040
T61153
Withdrawn 2.0
w237
External IDs
45
Properties
(calculated by RDKit )
Molecular Weight
310.15
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
0
Rotatable Bonds
2
Ring Count
4
Aromatic Ring Count
2
cLogP
4.63
TPSA
6.48
Fraction CSP3
0.37
Chiral centers
1.0
Largest ring
6.0
QED
0.8
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Apoptosis
MALT1
ATC
N06AX13
Toxicity type
neurological
Pathway
Metabolic Enzyme/Protease
NF-κB
Immunology/Inflammation
NF-¦ÊB
Source data