General
Preferred name
REBOXETINE
Synonyms
FCE20124 mesylate ()
Edronax ()
PNU155950E mesylate ()
PNU 155950E ()
REBOXETINE MESYLATE ()
Reboxetine (mesylate) ()
FCE20124 (mesylate) ()
PNU155950E (mesylate) ()
PNU 155950E, FCE20124 mesylate ()
P&D ID
PD014779
CAS
141425-90-3
98769-84-7
98769-81-4
71620-89-8
Tags
available
drug
First approval
1997
Drug indication
Depression
Drug Status
approved
experimental
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Reboxetine mesylate (FCE20124 mesylate) is a potent, selective, and specific noradrenaline reuptake inhibitor (NARI) for the research of depression. Reboxetine mesylate inhibits the uptake of norepinephrine, with a Ki of 8 nM[1].
PRICE
54
METABOLISM
Reboxetine is metabolized by dealkylation, hydroxylation and oxidation followed; by glucuronide or sulphate conjugation. It is metabolized by the cytochrome P450; CYP isoenzyme 3A4.
DESCRIPTION
Reboxetine mesylate (FCE20124 mesylate) is a norepinephrine reuptake inhibitor with a Ki of 8.2 nM.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
14
AdooQ Bioactive Compound Library
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
MedChem Express Bioactive Compound Library
NPC Screening Collection
Other bioactive compounds
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
45
Molecular Weight
313.17
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
1
Rotatable Bonds
6
Ring Count
3
Aromatic Ring Count
2
cLogP
3.19
TPSA
39.72
Fraction CSP3
0.37
Chiral centers
2.0
Largest ring
6.0
QED
0.89
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Indication
depression
Target
SLC6A2
Adrenergic Receptor
norepinephrine reuptake
MOA
Adrenergic Receptor antagonist
Pathway
GPCR/G protein
Neuroscience
Neuronal Signaling
Therapeutic Class
Antidepressants
Source data
