General
Preferred name
OXIDOPAMINE
Synonyms
OXIDOPAMINE HYDROCHLORIDE ()
6-Hydroxydopamine hydrochloride ()
6-OHDA hydrochloride ()
Oxidopamine (hydrochloride) ()
Oxidopamine (hydrobromide) ()
6-Hydroxydopamine hydrobromide ()
6-OHDA hydrobromide ()
Oxidopamine hydrobromide ()
6-hydroxydopamine ()
6-OHDA ()
2,4,5-trihydroxyphenethylamine ()
6-Hydroxydopamine HCl ()
6-OHDA (hydrobromide) ()
P&D ID
PD014744
CAS
28094-15-7
1199-18-4
636-00-0
Tags
drug candidate
natural product
available
Drug indication
Adrenergic (ophthalmic)
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION 6-Hydroxydopamine hydrobromide is a selective catecholaminergic neurotoxin. 6-Hydroxydopamine hydrobromide is used to produce animal model of Parkinson's disease via causing almost complete destruction of nigral dopaminergic neurons and their striatal terminals when injected into the substantia nigra of rats. (BOC Sciences Bioactive Compounds)
Cell lines
0
Organisms
1
Compound Sets
10
BOC Sciences Bioactive Compounds
6-hydroxydopamine-hydrobromide-cas-636-00-0-30727
Cayman Chemical Bioactives
25330
ChEMBL Drugs
CHEMBL337702
Drug Repurposing Hub
DrugMatrix
MedChem Express Bioactive Compound Library
HY-B1081
HY-B1081A
NPC Screening Collection
Selleckchem Bioactive Compound Library
oxidopamine-hydrobromide
TargetMol Bioactive Compound Library
T12352
The Spectrum Collection
External IDs
52
Properties
(calculated by RDKit )
Molecular Weight
169.07
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
4
Rotatable Bonds
2
Ring Count
1
Aromatic Ring Count
1
cLogP
0.3
TPSA
86.71
Fraction CSP3
0.25
Chiral centers
0.0
Largest ring
6.0
QED
0.38
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
GPCR/G protein
Neuroscience
Apoptosis
Autophagy
Immunology/Inflammation
MAPK/ERK Pathway
Neuronal Signaling
Target
dopamine
Caspase
COX
Dopamine Receptor
Interleukin Related
Mitophagy
p38 MAPK
PGE synthase
MOA
neurotoxin
Solubility
Soluble in DMSO (Slightly), Methanol (Slightly), Water (Slightly)
Source data