General
Preferred name
TIOTIDINE
Synonyms
CHEMBL269646 ()
ICI 125211 ()
[3H]tiotidine ()
ICI 125,211 ()
ICI-125,211 ()
ICI-125211 ()
P&D ID
PD014740
CAS
69014-14-8
145066-38-2
Tags
drug candidate
probe
biased GPCR ligand
available
Drug indication
Antagonist (to histamine-H2 receptors)
Discovery agent
Probe info
Probe selectivity
protein-selective
Probe type
P&D approved
calculated probe
Probe sources
High-quality chemical probes
Tool Compound Set
Probe targets
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Potent, selective H2 antagonist (Tocriscreen Plus)
DESCRIPTION beta antagonist. More active enantiomer of propranolol (Cat. No. 0624) (Tocris Bioactive Compound Library)
DESCRIPTION Potent, selective H2 antagonist (Tocriscreen Total)
DESCRIPTION Tiotidine is a potent histamine H2 receptor antagonist with negligible activity against H1- and H3- receptors. (BOC Sciences Bioactive Compounds)
Compound Sets
22
BiasDB
Tiotidine
BOC Sciences Bioactive Compounds
tiotidine-cas-69014-14-8-item-77059
ChEMBL Drugs
CHEMBL269646
Concise Guide to Pharmacology 2017/18
3959
1235
Concise Guide to Pharmacology 2019/20
3959
1235
Concise Guide to Pharmacology 2021/22
3959
1235
Concise Guide to Pharmacology 2023/24
3959
1235
Drug Repurposing Hub
DrugMAP
DM81KD2
DrugMatrix
Guide to Pharmacology
3959
1235
High-quality chemical probes
PD014740
Ki Database
Tiotidine
Mcule NIBR MoA Box Subset
MCULE-7820091314
MedChem Express Bioactive Compound Library
HY-101232
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
ReFrame library
Tocris Bioactive Compound Library
0826
Tocriscreen Plus
0826
Tocriscreen Total
Tool Compound Set
External IDs
27
Properties
(calculated by RDKit )
Molecular Weight
312.09
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
4
Rotatable Bonds
6
Ring Count
1
Aromatic Ring Count
1
cLogP
-0.07
TPSA
137.5
Fraction CSP3
0.4
Chiral centers
0.0
Largest ring
5.0
QED
0.25
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target Type
7-TM Receptors
Target
Histamine H2 receptor
HRH2
Histamine Receptor
Primary Target
Histamine H2 Receptors
MOA
Antagonist
HRH2 antagonist
Histamine Receptor antagonist
Member status
virtual
Pathway
GPCR/G protein
Immunology/Inflammation
Neuronal Signaling
Source data