General
Preferred name
GALLOPAMIL
Synonyms
(±)-Methoxyverapamil hydrochloride ()
Methoxyverapamil ()
D600 ()
Gallopamil (hydrochloride) ()
Methoxyverapamil (hydrochloride) ()
(+/-)-Methoxyverapamil HCl ()
METHOXYVERAPAMIL HYDROCHLORIDE ()
P&D ID
PD014655
CAS
16662-47-8
56949-75-8
16662-46-7
Tags
natural product
drug
available
Drug indication
Hypertension
Asthma
Drug Status
investigational
approved
Max Phase
Phase 2
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION L-type Ca2+ channel antagonist (LOPAC library)
DESCRIPTION (±)-Methoxyverapamil is a phenylalkylamine L-type calcium channel blocker and methoxy derivative of verapamil. (±)-Methoxyverapamil blocks recombinant rat L-type calcium channels expressed in tsA201 cells with IC50 values of 782 and 8,000 nM at holding potentials of 10 and -60 mV, respectively. (BOC Sciences Bioactive Compounds)
Cell lines
0
Organisms
2
Compound Sets
14
BOC Sciences Bioactive Compounds
3-cyano-3-3-4-5-trimethoxyphenyl-hex-6-yl-5-6-dimethoxyphenethyl-cas-16662-46-7-item-60526
ChEMBL Drugs
CHEMBL51149
Drug Repurposing Hub
DrugBank
DB12923
DrugCentral
1275
DrugCentral Approved Drugs
1275
DrugMAP
DMXBR27
DrugMatrix
Ki Database
D600
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL51149
MedChem Express Bioactive Compound Library
HY-14276A
NPC Screening Collection
ReFrame library
External IDs
44
Properties
(calculated by RDKit )
Molecular Weight
484.29
Hydrogen Bond Acceptors
7
Hydrogen Bond Donors
0
Rotatable Bonds
14
Ring Count
2
Aromatic Ring Count
2
cLogP
5.1
TPSA
73.18
Fraction CSP3
0.54
Chiral centers
1.0
Largest ring
6.0
QED
0.37
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
L-type
Target
Calcium Channel
ATP2A2
Pathway
Membrane Transporter/Ion Channel
Neuronal Signaling
Indication
hypertension, cardiac arrythmia
MOA
L-type calcium channel blocker
Source data