General
Preferred name
NIFENALOL
Synonyms
INPEA ()
Nifenalol (hydrochloride) ()
Nifenalol HCl ()
nifenalol.HCl ()
Racemic nifenalol ()
DL-INPEA ()
P&D ID
PD014639
CAS
5704-60-9
74-10-2
5054-57-9
7413-36-7
Tags
available
drug
Drug Status
investigational
approved
Max Phase
2.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Nifenalol hydrochloride is a ¦Â-adrenergic receptor antagonist. Nifenalol hydrochloride induces the Early Afterdepolarization (EAD) effect. EAD is a phenomenon in cardiac electrophysiology that usually occurs during an action potential in ventricular muscle cells and can lead to arrhythmia. The EAD effect of Nifenalol hydrochloride can be blocked by Tetrodotoxin. Nifenalol hydrochloride is used in the study of conditions such as irregular heartbeat or high blood pressure[1].
PRICE
29
DESCRIPTION
Nifenalol.HCl(INPEA) is a antagonist of ??-adrenergic receptor.
DESCRIPTION
Nifenalol is an antagonist of beta-adrenergic receptor.
(Enamine Bioactive Compounds)
DESCRIPTION
Nifenalol, also known as INPEA, is a novel antagonist of β-adrenoceptors.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
Nifenalol.HCl(INPEA) is a antagonist of β-adrenergic receptor.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
11
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
ChEMBL Drugs
DrugCentral
DrugCentral Approved Drugs
Enamine Bioactive Compounds
Enamine BioReference Compounds
MedChem Express Bioactive Compound Library
NPC Screening Collection
ReFrame library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
31
Molecular Weight
224.12
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
2
Rotatable Bonds
5
Ring Count
1
Aromatic Ring Count
1
cLogP
1.63
TPSA
75.4
Fraction CSP3
0.45
Chiral centers
1.0
Largest ring
6.0
QED
0.59
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
β-adrenergic receptor
Adrenergic Receptor
Pathway
GPCR/G protein
Neuroscience
Neuronal Signaling
Solubility
Soluble in DMSO.
Source data
