General
Preferred name
PAMOIC ACID
Synonyms
Pivampicillin pamoate ()
CHEMBL177880 ()
P&D ID
PD014574
CAS
130-85-8
108626-78-4
Tags
drug candidate
natural product
probe
available
Drug indication
Discovery agent
Probe info
Probe selectivity
protein-selective
Probe type
P&D approved
calculated probe
Probe sources
High-quality chemical probes
Tool Compound Set
Probe targets
[[ compound.targets[t].gene_name ]]
Probe control
Probe control not defined
Orthogonal probes
4
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Many salts and esters or pamoates are commecially available and are often used in bio-assays in place of pamoic acid.
Although not an approved drug itself, pamoic acid is a component of the INN-assigned compounds listed above. (GtoPdb)
Although not an approved drug itself, pamoic acid is a component of the INN-assigned compounds listed above. (GtoPdb)
DESCRIPTION
Pamoic acid is a potent agonist of GPR35 orphan receptors with antinociceptive effects. It was shown to activate ERK and beta-arrestin2.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
15
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
Drug Repurposing Hub
DrugMAP
EU-OPENSCREEN Bioactive Compound Library
EUbOPEN Chemogenomics Library
Guide to Pharmacology
High-quality chemical probes
Mcule NIBR MoA Box Subset
MedChem Express Bioactive Compound Library
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
TargetMol Bioactive Compound Library
Tool Compound Set
ZINC Tool Compounds
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
29
Molecular Weight
388.09
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
4
Rotatable Bonds
4
Ring Count
4
Aromatic Ring Count
4
cLogP
4.39
TPSA
115.06
Fraction CSP3
0.04
Chiral centers
0.0
Largest ring
6.0
QED
0.41
Structural alerts
1
aggregator (ZINC)
Aggregators
Related compounds
Custom attributes
(extracted from source data)
Target
G-protein coupled receptor 35
GPR35
ERK
Pathway
Endocrinology/Hormones
GPCR/G protein
MAPK/ERK Pathway
Stem Cell/Wnt
Member status
member
MOA
G Protein-Coupled Receptor GPR35 Agonists
acetylcholine receptor agonist, nicotinic receptor agonist
Indication
gastrointestinal roundworms
Source data
