General
Preferred name
cilomilast
Synonyms
SB-207499 ()
Ariflo ()
SB 207499 ()
P&D ID
PD014563
CAS
153259-65-5
Tags
available
drug candidate
Drug Status
investigational
Max Phase
Phase 3
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION There is some ambiguity in the literature and on other database as to the exact structure of Cilomilast. The structure shown here matches that of the INN document, but the compound is represented on PubChem without specified stereochemistry by CID 151170. (GtoPdb)
Cell lines
2
Organisms
4
Compound Sets
11
Cayman Chemical Bioactives
25979
ChEMBL Drugs
CHEMBL511115
Drug Repurposing Hub
DrugBank
DB03849
EU-OPENSCREEN Bioactive Compound Library
EOS100607
Guide to Pharmacology
7407
MedChem Express Bioactive Compound Library
HY-10790
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
ReFrame library
TargetMol Bioactive Compound Library
T6445
External IDs
25
Properties
(calculated by RDKit )
Molecular Weight
343.18
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
1
Rotatable Bonds
5
Ring Count
3
Aromatic Ring Count
1
cLogP
4.05
TPSA
79.55
Fraction CSP3
0.6
Chiral centers
0.0
Largest ring
6.0
QED
0.87
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Metabolism
Metabolic Enzyme/Protease
Target
HPDE4
LPDE4
PDE4A, PDE4B, PDE4D
Phosphodiesterase (PDE)
MOA
PDE inhibitor
IL-12 Production Inhibitors
Phosphodiesterase IV Inhibitors
TNF-alpha Production Inhibitors
IL-1beta Production Inhibitors
phosphodiesterase inhibitor
Member status
member
Source data