General
Preferred name
RIMCAZOLE
Synonyms
BW 234U (dihydrochloride) ()
Rimcazole dihydrochloride ()
Rimcazole (dihydrochloride) ()
BW-234U ()
BW 234U ()
Rimcazol ()
BW 234U DIHYDROCHLORIDE ()
RIMCAZOLE HYDROCHLORIDE ()
P&D ID
PD014554
CAS
75859-03-9
75859-04-0
108050-82-4
207233-98-5
Tags
available
drug candidate
Drug indication
Schizophrenia
Antipsychotic
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
GABA uptake inhibitor
(Tocris Bioactive Compound Library)
DESCRIPTION
σ2 antagonist. Also DAT inhibitor
(Tocriscreen Total)
DESCRIPTION
Rimcazole dihydrochloride is a small molecule antagonist of the σ-1 receptor (IC50 values are 1480 and 386 nM at σ1 and σ2 receptors respectively).
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
11
BOC Sciences Bioactive Compounds
ChEMBL Drugs
Drug Repurposing Hub
DrugMAP
MedChem Express Bioactive Compound Library
NIH Clinical Collections (NCC)
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
ReFrame library
Tocris Bioactive Compound Library
Tocriscreen Total
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
44
Molecular Weight
321.22
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
1
Rotatable Bonds
4
Ring Count
4
Aromatic Ring Count
3
cLogP
3.87
TPSA
20.2
Fraction CSP3
0.43
Chiral centers
2.0
Largest ring
6.0
QED
0.79
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Primary Target
?2 Receptors
MOA
Antagonist
sigma Receptor Antagonists
Sigma receptor antagonist
Member status
member
Target
SIGMAR1
Dopamine Receptor
Sigma Receptor
Pathway
GPCR/G protein
Neuronal Signaling
Source data
