General
Preferred name
ACEGLUMATE
Synonyms
Deanol aceglutamate ()
Ac-L-Glu-OH ()
N-Acetylglutamic acid ()
N-Acetyl-L-glutamic acid ()
DEANOL ACEGLUMATE ()
deanol ()
Aceglumato de deanol ()
NSC-2652 ()
Oristar dmae ()
Aceglumate de deanol ()
Dimethyl mea ()
P&D ID
PD014523
CAS
1188-37-0
5817-08-3
Tags
available
drug candidate
Drug Status
investigational
Max Phase
2.0
Drug indication
Attention deficit hyperactivity disorder
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE
29
DESCRIPTION
N-Acetyl-L-glutamic acid (Ac-L-Glu-OH) (NAcGlu) is an acetylated amino acid. NAcGlu is biosynthesized from glutamic acid and acetyl-CoA by the enzyme N-acetyl glutamate synthase (NAGS). NAcGlu activates carbamoyl phosphate synthetase in the urea cycle. A deficiency in N-acetyl glutamate synthase or a genetic mutation in the gene coding for the enzyme will lead to urea cycle failure in which ammonia is not converted to urea, but rather accumulated in the blood leading to the condition called Type I hyperammonemia.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
3
ChEMBL Drugs
NPC Screening Collection
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
25
Molecular Weight
189.06
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
3
Rotatable Bonds
5
Ring Count
0
Aromatic Ring Count
0
cLogP
-0.56
TPSA
103.7
Fraction CSP3
0.57
Chiral centers
1.0
Largest ring
0.0
QED
0.54
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Endogenous Metabolite
Pathway
Metabolism
Source data
