General
Preferred name
ZACOPRIDE
Synonyms
ZACOPRIDE HYDROCHLORIDE ()
Zacopride HCl ()
AHR-11190-B ()
(R)-ZACOPRIDE ()
ZACOPRIDE,R ()
ZACOPRIDE,S ()
Zacopride (hydrochloride) ()
P&D ID
PD014511
CAS
101303-98-4
99617-34-2
90182-92-6
Tags
drug candidate
natural product
available
Drug indication
Anti-Emetic
Stimulant (peristaltic)
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
KV11.1 (hERG) channel blocker; inhibits rapid delayed rectifier K+ current (IKr)
(Tocris Bioactive Compound Library)
DESCRIPTION
Highly potent 5-HT3 receptor antagonist. Also 5-HT4 agonist
(Tocriscreen Plus)
DESCRIPTION
Highly potent 5-HT3 receptor antagonist. Also 5-HT4 agonist
(Tocriscreen Total)
DESCRIPTION
Zacopride hydrochloride is a highly potent 5-HT3 receptor antagonist (Ki = 0.38 nM) and 5-HT4 receptor agonist (Ki = 373 nM). Zacopride hydrochloride acts as an antiemetic and anxiolytic following systemic administration in vivo.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
13
BOC Sciences Bioactive Compounds
ChEMBL Drugs
DrugMatrix
Guide to Pharmacology
Ki Database
MedChem Express Bioactive Compound Library
NIH Clinical Collections (NCC)
NPC Screening Collection
ReFrame library
TargetMol Bioactive Compound Library
Tocris Bioactive Compound Library
Tocriscreen Plus
Tocriscreen Total
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
42
Molecular Weight
309.12
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
2
Rotatable Bonds
3
Ring Count
4
Aromatic Ring Count
1
cLogP
1.75
TPSA
67.59
Fraction CSP3
0.53
Chiral centers
1.0
Largest ring
6.0
QED
0.83
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
Ion Channels
Pathway
GPCR/G protein
Membrane Transporter/Ion Channel
Neuroscience
Neuronal Signaling
Target
5-HT3 antagonist
5-HT4 agonist
IK1/Kir2.1 agonist
Primary Target
5-HT3 Receptors
MOA
Antagonist
5-HT Receptor
Potassium Channel
Source data
