General
Preferred name
ZACOPRIDE
Synonyms
ZACOPRIDE HYDROCHLORIDE ()
Zacopride HCl ()
AHR-11190-B ()
(R)-ZACOPRIDE ()
ZACOPRIDE,R ()
ZACOPRIDE,S ()
Zacopride (hydrochloride) ()
Zacoprida ()
P&D ID
PD014511
CAS
101303-98-4
99617-34-2
90182-92-6
Tags
available
drug candidate
Drug Status
investigational
Max Phase
2.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Zacopride hydrochloride is an orally active 5-HT3 receptor (Ki of 0.38 nM) antagonist and 5-HT4 receptor (Ki of 373 nM) agonist. Zacopride hydrochloride exhibits multiple activities, such as regulating gastrointestinal motility, affecting cardiac function, and exerting anxiolytic and antiemetic effects. Zacopride hydrochloride is currently mainly used in the research of gastrointestinal diseases, cardiovascular diseases, and psychiatric diseases such as anxiety[1][2][3][4][5][6][7][8][9][10][11].
PRICE 111
DESCRIPTION KV11.1 (hERG) channel blocker; inhibits rapid delayed rectifier K+ current (IKr) (Tocris Bioactive Compound Library)
DESCRIPTION Highly potent 5-HT3 receptor antagonist. Also 5-HT4 agonist (Tocriscreen Plus)
DESCRIPTION Highly potent 5-HT3 receptor antagonist. Also 5-HT4 agonist (Tocriscreen Total)
DESCRIPTION Zacopride hydrochloride is a highly potent 5-HT3 receptor antagonist (Ki = 0.38 nM) and 5-HT4 receptor agonist (Ki = 373 nM). Zacopride hydrochloride acts as an antiemetic and anxiolytic following systemic administration in vivo. (BOC Sciences Bioactive Compounds)
DESCRIPTION Zacopride is a highly potent 5-HT3 receptor antagonist (Kd = 0.38 nM) and 5-HT4 receptor agonist (Ki = 373 nM). It also is a selective IK1 channel agonist. (TargetMol Bioactive Compound Library)
Compound Sets
15
BOC Sciences Bioactive Compounds
zacopride-hydrochloride-cas-101303-98-4-357688
ChEMBL Drugs
CHEMBL1516756
CHEMBL18041
CZ-OPENSCREEN Bioactive Library
DrugMatrix
EUbOPEN Chemogenomics Library
EUB0001967
Guide to Pharmacology
245
Ki Database
ZACOPRIDE
ZACOPRIDE,R
ZACOPRIDE,S
MedChem Express Bioactive Compound Library
HY-103137
NIH Clinical Collections (NCC)
NPC Screening Collection
ReFrame library
TargetMol Bioactive Compound Library
T5336
Tocris Bioactive Compound Library
1795
Tocriscreen Plus
1795
Tocriscreen Total
External IDs
44
Properties
(calculated by RDKit )
Molecular Weight
309.12
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
2
Rotatable Bonds
3
Ring Count
4
Aromatic Ring Count
1
cLogP
1.75
TPSA
67.59
Fraction CSP3
0.53
Chiral centers
1.0
Largest ring
6.0
QED
0.83
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
Ion Channels
Target
5-HT3
5-HT4
IK1
Kir2.1
Primary Target
5-HT3 Receptors
MOA
Antagonist
5-HT Receptor
Potassium Channel
Pathway
GPCR/G protein
Neuronal Signaling
Membrane Transporter/Ion Channel
Neuroscience
Recommended Cell Concentration
10 nM
Source data