General
Preferred name
methysergide
Synonyms
METHYSERGIDE MALEATE ()
Deseril ()
Methysergide ()
Sansert ()
Methysergide (maleate) ()
P&D ID
PD014446
CAS
361-37-5
156558-44-0
1257-58-5
129-49-7
Tags
natural product
drug
available
Approved by
FDA
First approval
1962
Drug indication
Migraine
Vasoconstrictor (specific in migraine)
Drug Status
approved
withdrawn
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Methysergide is an ergot alkaloid. When used, this drug is administered as methysergide maleate (PubChem CID 5281073). The use of ergot alkaloids has been discontinued or restricted due to their propensity to cause fibrosis.
(GtoPdb)
DESCRIPTION
Serotonin receptor antagonist; antimigraine
(LOPAC library)
DESCRIPTION
High affinity, selective D4 agonist
(Tocris Bioactive Compound Library)
DESCRIPTION
5-HT1/5-HT2 antagonist
(Tocriscreen Total)
DESCRIPTION
Methysergide is a prescription drug formerly used for prophylaxis of cluster headaches/migraine headaches, but is no longer recommended due to retroperitoneal/retropulmonary fibrosis. Methysergide maleate is a nonselective 5-HT1, 5-HT2, and 5-HT7 serotonin receptor antagonist.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
22
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
Drug Repurposing Hub
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
Guide to Pharmacology
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
NPC Screening Collection
ReFrame library
Selleckchem Bioactive Compound Library
The Spectrum Collection
Tocris Bioactive Compound Library
Tocriscreen Total
Withdrawn 2.0
ZINC Tool Compounds
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
42
Molecular Weight
353.21
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
2
Rotatable Bonds
4
Ring Count
4
Aromatic Ring Count
2
cLogP
1.94
TPSA
57.5
Fraction CSP3
0.48
Chiral centers
3.0
Largest ring
6.0
QED
0.88
Structural alerts
2
aggregator (Aggregator Advisor)
Aggregators
aggregator (ZINC)
Aggregators
Related compounds
Custom attributes
(extracted from source data)
Primary Target
Non-selective 5-HT
MOA
Antagonist
serotonin receptor antagonist
Indication
headache
Target
HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR5A, HTR6, HTR7
5-HT Receptor
ATC
N02CA04
Therapeutic Class
Vasoconstrictor Agents
Source data
