General
Preferred name
LORGLUMIDE
Synonyms
LORGLUMIDE SODIUM ()
CR 1409 ()
CR-1409 sodium salt ()
Lorglumide sodium salt ()
BIO-306 ()
CR-1409 (sodium salt) ()
Lorglumide (sodium salt) ()
Lorglumida ()
CR-1409 ()
P&D ID
PD014445
CAS
97964-56-2
1021868-76-7
Tags
available
drug candidate
Drug indication
Migraine
Pancreatic malfunction
Drug Status
investigational
Max Phase
2.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Lorglumide sodium salt (CR-1409 sodium salt) is a potent cholecystokinin (CCK) receptor antagonist[1].
PRICE 41
DESCRIPTION The INN-assigned compound is a racemic mixture of two enantiomers. The structure shown here does not specify stereochemistry and represents the mixture. (GtoPdb)
DESCRIPTION Potent and selective non-peptide cholecystokinin (CCK) receptor antagonist; orally active (LOPAC library)
DESCRIPTION Lorglumide sodium is a potent and selective cholecystokinin A (CCKA) antagonist. CCKA is a peptide hormone of the gastrointestinal system that promotes fat and protein digestion. Lorglumide is used as a drug suppressing gastrointestinal motility and reducing gastric secretions. (BOC Sciences Bioactive Compounds)
DESCRIPTION Lorglumide sodium salt (CR-1409 sodium salt) is an antagonist of cholecystokinin receptors (CCK). (TargetMol Bioactive Compound Library)
Cell lines
3
Organisms
0
Compound Sets
20
BOC Sciences Bioactive Compounds
lorglumide-sodium-salt-cas-1021868-76-7-357838
Cayman Chemical Bioactives
17555
ChEMBL Drugs
CHEMBL24938
Concise Guide to Pharmacology 2017/18
891
Concise Guide to Pharmacology 2019/20
891
Concise Guide to Pharmacology 2021/22
891
Concise Guide to Pharmacology 2023/24
891
CZ-OPENSCREEN Bioactive Library
DrugMAP
DMPUBK8
DM904B6
DrugMatrix
Guide to Pharmacology
891
Ki Database
CR 1409
LOPAC library
MedChem Express Bioactive Compound Library
HY-B1439B
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
TargetMol Bioactive Compound Library
T11868
The Spectrum Collection
External IDs
31
Properties
(calculated by RDKit )
Molecular Weight
458.17
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
2
Rotatable Bonds
14
Ring Count
1
Aromatic Ring Count
1
cLogP
5.17
TPSA
86.71
Fraction CSP3
0.59
Chiral centers
1.0
Largest ring
6.0
QED
0.38
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
CCK-A
Target
CCK
Cholecystokinin Receptor
Member status
member
MOA
CCK1 (CCKA) Antagonists
Pathway
GPCR/G protein
Neuronal Signaling
Source data