General
Preferred name
OXOMEMAZINE
Synonyms
Oxomemazinum ()
Exe-top ()
Oxomemazina ()
Trimeprazine 5,5-dioxide ()
6487-RP ()
RP 6847 ()
Oplex ()
6847-RP ()
Imakol ()
Doxergan ()
Dysedon ()
RP-6847 ()
(±)-Oxomemazine ()
P&D ID
PD014405
CAS
3689-50-7
Tags
available
drug
Drug Status
approved
withdrawn
experimental
investigational
Max Phase
3.0
Drug indication
Cough
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Oxomemazine is a phenothiazine-based histamine H1-receptor blocker with pronounced antimuscarinic properties. Oxomemazine is a selective antagonist for muscarinic M1 receptor, displays about 20-fold difference in the affinity for high (Ki = 84 nM, M1 receptor) and low (Ki = 1.65 ¦ÌM, M2 receptor) affinity sites[1]. Oxomemazine?an antihistamine and anticholinergic agent used for the study of cough treatment[2].
PRICE 29
DESCRIPTION Oxomemazine is a phenothiazine-based histamine H1-receptor blocker with pronounced antimuscarinic activity. It is a selective antagonist of mycotoxins M1 receptors, exhibiting high (Ki=84 nM, M1 receptors) and low (Ki=1.65 ??M, M2 receptors) affinity, with a 20-fold difference. Oxomemazine is an antihistamine and anticholinergic agent used in cough studies[1][2].
DESCRIPTION Oxomemazine is a phenothiazine-based histamine H1-receptor blocker with pronounced antimuscarinic activity. It is a selective antagonist of mycotoxins M1 receptors, exhibiting high (Ki=84 nM, M1 receptors) and low (Ki=1.65 μM, M2 receptors) affinity, with a 20-fold difference. Oxomemazine is an antihistamine and anticholinergic agent used in cough studies[1][2]. (TargetMol Bioactive Compound Library)
Compound Sets
10
Cayman Chemical Bioactives
39511
ChEMBL Drugs
CHEMBL2104734
DrugBank
DB13820
DrugCentral
2025
DrugCentral Approved Drugs
2025
DrugMatrix
MedChem Express Bioactive Compound Library
HY-136587
NPC Screening Collection
TargetMol Bioactive Compound Library
T9353
Withdrawn 2.0
w246
External IDs
25
Properties
(calculated by RDKit )
Molecular Weight
330.14
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
0
Rotatable Bonds
4
Ring Count
3
Aromatic Ring Count
2
cLogP
3.17
TPSA
40.62
Fraction CSP3
0.33
Chiral centers
1.0
Largest ring
6.0
QED
0.86
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Pathway
GPCR/G protein
Immunology/Inflammation
Neuroscience
Neuronal Signaling
ATC
R06AD08
Target
Histamine Receptor
mGluR
H1 receptor
M1 mAChR
Source data