General
Preferred name
Oxogluric acid
Synonyms
Alpha-keto-glutaric acid, sodium salt ()
2-oxoglutaric-acid ()
ALPHA-KETOGLUTARIC ACID ()
2-Ketoglutaric acid ()
2-Oxoglutaric acid ()
alpha-ketoglutarate, alpha-ketoglutaric acid, 2-oxoglutaric acid ()
α-ketoglutaric acid ()
?-Ketoglutaric Acid ()
P&D ID
PD014389
CAS
34410-46-3
27175-99-1
17091-15-5
328-50-7
Tags
available
covalent binder
drug candidate
Drug indication
Discovery agent
Drug Status
experimental
nutraceutical
investigational
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE
29
DESCRIPTION
Alpha-ketoglutaric acid is a potent inhibitor of mutant isocitrate dehydrogenase IDH1.
(Enamine Bioactive Compounds)
DESCRIPTION
2-Ketoglutaric acid is a key molecule in the tricarboxylic acid cycle,is also connected to glutamic acid and glutamine metabolisms through the transamination reactions.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
17
Cayman Chemical Bioactives
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
Drug Repurposing Hub
DrugBank
DrugMAP
Enamine Bioactive Compounds
Enamine BioReference Compounds
Guide to Pharmacology
MedChem Express Bioactive Compound Library
NPC Screening Collection
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
46
Molecular Weight
146.02
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
2
Rotatable Bonds
4
Ring Count
0
Aromatic Ring Count
0
cLogP
-0.5
TPSA
91.67
Fraction CSP3
0.4
Chiral centers
0.0
Largest ring
0.0
QED
0.52
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Endogenous Metabolite
Human Endogenous Metabolite
Tyrosinase
OXGR1
Pathway
Metabolism
Proteases/Proteasome
Metabolic Enzyme/Protease
Source data
