General
Preferred name
TESAGLITAZAR
Synonyms
AZ 242 ()
Galida ()
AR-H-039242 ()
AR-H039242XX ()
AZ-242 ()
BR-44608 ()
P&D ID
PD014363
CAS
251565-85-2
Tags
available
drug candidate
Drug indication
Type-1 diabetes
Drug Status
investigational
Max Phase
Phase 3
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION PPARalpha/gamma agonist (Tocriscreen Plus)
DESCRIPTION Estrogen receptor ligand; mycotoxin (Tocris Bioactive Compound Library)
DESCRIPTION Tesaglitazar is a dual-acting agonist of PPARα/γ (IC50 = 0.35 and 3.8 μM for PPARγ and PPARα, respectively). It reduces insulin resistance in obese Zucker rats that has the potential for the treatment of type 2 diabetes. Tesaglitazar also prevents atherosclerosis progression in E3L.CETP transgenic mice. (BOC Sciences Bioactive Compounds)
Compound Sets
14
BOC Sciences Bioactive Compounds
tesaglitazar-cas-251565-85-2-item-103606
Cayman Chemical Bioactives
16791
ChEMBL Drugs
CHEMBL282686
Drug Repurposing Hub
DrugBank
DB06536
DrugMAP
DMGRBN5
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL282686
MedChem Express Bioactive Compound Library
HY-17444
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
NURSA ligand set
nursa/index.jsf?doi=10.1621%2FCWFK1YR86Z
ReFrame library
Tocris Bioactive Compound Library
3965
Tocriscreen Plus
3965
External IDs
28
Properties
(calculated by RDKit )
Molecular Weight
408.12
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
1
Rotatable Bonds
11
Ring Count
2
Aromatic Ring Count
2
cLogP
2.68
TPSA
99.13
Fraction CSP3
0.35
Chiral centers
1.0
Largest ring
6.0
QED
0.57
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
Nuclear Receptors
Primary Target
Non-selective PPAR
MOA
Agonist
Insulin Sensitizers
PPARalpha Agonists
PPARgamma Agonists
insulin sensitizer, PPAR receptor agonist
Member status
member
Target
PPARA, PPARG
PPAR
Pathway
Cell Cycle/DNA Damage
Vitamin D Related/Nuclear Receptor
Source data