General
Preferred name
TROVAFLOXACIN
Synonyms
TROVAFLOXACIN MESYLATE ()
Trovafloxacin (mesylate) ()
Trovafloxacin mesilate ()
CP-99,219-27 ()
Trovan ()
Trovafloxacin methanesulfonate ()
Trovafloxacin sulfate ()
CP-99219-27 ()
CP-99219 ()
P&D ID
PD014319
CAS
147059-75-4
147059-72-1
Tags
available
drug
Approved by
FDA
First approval
1997
Drug Status
investigational
approved
withdrawn
Max Phase
Phase 4
Drug indication
Antibacterial
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Inducer of neuronal differentiation in MSCs
(Tocris Bioactive Compound Library)
DESCRIPTION
Antibiotic; inhibits bacterial DNA synthesis
(Tocriscreen Plus)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
1
Organisms
3
Compound Sets
16
Axon Medchem Screening Library
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
LSP-MoA library (Laboratory of Systems Pharmacology)
NPC Screening Collection
ReFrame library
Tocris Bioactive Compound Library
Tocriscreen Plus
Withdrawn 2.0
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
42
Molecular Weight
416.11
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
2
Rotatable Bonds
3
Ring Count
5
Aromatic Ring Count
3
cLogP
1.89
TPSA
101.45
Fraction CSP3
0.25
Chiral centers
3.0
Largest ring
6.0
QED
0.68
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
Cell Biology
Primary Target
DNA, RNA and Protein Synthesis
MOA
Inhibitor
bacterial DNA gyrase inhibitor
Target
TOP2A
Topo IV inhibitor
antibiotic
Bacterial
Topoisomerase
ATC
J01MA13
Toxicity type
hepatic
Pathway
Anti-infection
Cell Cycle/DNA Damage
Source data
