General
Preferred name
ENOXOLONE
Synonyms
18¦Â-Glycyrrhetinic acid ()
18??-Glycyrrhetinic acid ()
Glycyrrhetin ()
18??Glycyrrhetinic acid ()
Glycyrrhetinic acid ()
18beta-Glycyrrhetic acid ()
18β-Glycyrrhetinic acid ()
Rhetinic Acid ()
Glycyrrhetic Acid ()
NSC-35347 ()
Uralenic Acid ()
NSC-35350 ()
18.beta.-Glycyrrhetinic Acid ()
P&D ID
PD014316
CAS
471-53-4
107420-91-7
Tags
natural product
drug
available
Drug indication
Discovery agent
Drug Status
investigational
approved
Max Phase
Phase 2
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Enoxolone is a bioactive metabolite of glycyrrhizin, which is a compound found in the liquorice plant Glycyrrhiza glabra. It has been found to inhibit enzymes that metabolise the prostaglandins PGE2 and PGF2α to their inactive metabolites, and 11β-hydroxysteroid dehydrogenases (HSD11B1, HSD11B2) which convert active cortisol to inactive cortisone. Enoxolone has proposed anti-inflammatory and antitussive effects as well as action against pathogens (viruses, fungal infections, bacterial infections) , and beneficial actions for the treatmant of gastric ulcers.
(GtoPdb)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
31
Organisms
4
Compound Sets
18
AdooQ Bioactive Compound Library
Cayman Chemical Bioactives
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugCentral
DrugCentral Approved Drugs
DrugMAP
EU-OPENSCREEN Bioactive Compound Library
Guide to Pharmacology
LSP-MoA library (Laboratory of Systems Pharmacology)
LSP-OptimalKinase library (Laboratory of Systems Pharmacology)
MedChem Express Bioactive Compound Library
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
ZINC Tool Compounds
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
41
Molecular Weight
470.34
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
2
Rotatable Bonds
1
Ring Count
5
Aromatic Ring Count
0
cLogP
6.41
TPSA
74.6
Fraction CSP3
0.87
Chiral centers
9.0
Largest ring
6.0
QED
0.46
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Metabolism
Metabolic Enzyme/Protease
Target
Dehydrogenase
HSD11B1
Endogenous Metabolite
Member status
member
MOA
11-beta-Hydroxysteroid Dehydrogenase Type 1 (11beta-HSD1) Inhibitors
11-beta-Hydroxysteroid Dehydrogenase Type 2 (11beta-HSD2) Inhibitors
17beta-Hydroxysteroid Dehydrogenase Type 3 (17beta-HSD3) Inhibitors
gap junction modulator
Disease Area
gastroenterology, otolaryngology
Indication
peptic ulcer disease (PUD), common cold
Source data
