General
Preferred name
ENOXOLONE
Synonyms
18¦Â-Glycyrrhetinic acid ()
18??Glycyrrhetinic acid ()
Glycyrrhetinic acid ()
18beta-Glycyrrhetic acid ()
18β-Glycyrrhetinic acid ()
Glycyrrhetin ()
18.beta.-Glycyrrhetinic Acid ()
NSC-35350 ()
Enoxolona ()
NSC-35347 ()
P&D ID
PD014316
CAS
107420-91-7
471-53-4
Tags
available
drug
Drug indication
Discovery agent
Skin ulcer
Drug Status
approved
investigational
Max Phase
2.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
18¦Â-Glycyrrhetinic acid is the major bioactive component of Glycyrrhiza uralensis and possesses anti-ulcerative, anti-inflammatory and antiproliferative properties.
DESCRIPTION
Enoxolone is a bioactive metabolite of glycyrrhizin, which is a compound found in the liquorice plant Glycyrrhiza glabra. It has been found to inhibit enzymes that metabolise the prostaglandins PGE2 and PGF2α to their inactive metabolites, and 11β-hydroxysteroid dehydrogenases (HSD11B1, HSD11B2) which convert active cortisol to inactive cortisone. Enoxolone has proposed anti-inflammatory and antitussive effects as well as action against pathogens (viruses, fungal infections, bacterial infections) , and beneficial actions for the treatmant of gastric ulcers.
(GtoPdb)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
32
Organisms
4
Compound Sets
18
AdooQ Bioactive Compound Library
Cayman Chemical Bioactives
ChEMBL Drugs
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DrugCentral
DrugCentral Approved Drugs
DrugMAP
EU-OPENSCREEN Bioactive Compound Library
Guide to Pharmacology
LSP-MoA library (Laboratory of Systems Pharmacology)
LSP-OptimalKinase library (Laboratory of Systems Pharmacology)
MedChem Express Bioactive Compound Library
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Selleckchem Bioactive Compound Library
ZINC Tool Compounds
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
44
Molecular Weight
470.34
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
2
Rotatable Bonds
1
Ring Count
5
Aromatic Ring Count
0
cLogP
6.41
TPSA
74.6
Fraction CSP3
0.87
Chiral centers
9.0
Largest ring
6.0
QED
0.46
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
MOA
Dehydrogenase
11-beta-Hydroxysteroid Dehydrogenase Type 1 (11beta-HSD1) Inhibitors
11-beta-Hydroxysteroid Dehydrogenase Type 2 (11beta-HSD2) Inhibitors
17beta-Hydroxysteroid Dehydrogenase Type 3 (17beta-HSD3) Inhibitors
gap junction modulator
Member status
member
Disease Area
gastroenterology, otolaryngology
Indication
peptic ulcer disease (PUD), common cold
Target
HSD11B1
Endogenous Metabolite
Pathway
Metabolic Enzyme/Protease
Source data
