General
Preferred name
ARTESUNATE
Synonyms
WR-256283 ()
Arinate ()
artenusate ()
Plasmotrin ()
Artesunic acid ()
Dihydroqinghaosu hemisuccinate ()
Zysunate ()
NSC-712571 ()
Arsumax ()
Saphnate ()
Qinghaozhi ()
.alpha.-artesunic acid ()
LJPC-0118 ()
Artesunatum ()
Artesunate-d4 ()
P&D ID
PD014289
CAS
88495-63-0
1316753-15-7
Tags
prodrug
natural product
drug
available
Approved by
EMA
FDA
First approval
2020
Drug Status
investigational
approved
Drug indication
Malaria
Max Phase
Phase 4
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCPRITION
A water-soluble, semi-synthetic derivative of the sesquiterpene lactone artemisinin with anti-malarial, anti-schistosomiasis, antiviral, and potential anti-neoplastic activities
DESCRIPTION
Artesunate is a semisynthetic derivative of , a natural product isolated from the qinghao or sweet wormwood plant (Artemisia annua). It contains an unusual endoperoxide bridge, believed to be responsible for the antimalarial activity of artemisinin and its derivatives.
Artesunate is a prodrug that is converted to the active metabolite (dihydroartemisinin).
The Malaria tab on this ligand page provides additional curator comments of relevance to the Guide to MALARIA PHARMACOLOGY. (GtoPdb)
Artesunate is a prodrug that is converted to the active metabolite (dihydroartemisinin).
The Malaria tab on this ligand page provides additional curator comments of relevance to the Guide to MALARIA PHARMACOLOGY. (GtoPdb)
DESCRIPTION
Bcl-2 family inhibitor; mimics BH3 and induces apoptosis in cancer cell lines
(Tocris Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
28
Organisms
14
Compound Sets
16
ChEMBL Approved Drugs
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
Guide to Pharmacology
MedChem Express Bioactive Compound Library
Natural product-based probes and drugs
NPC Screening Collection
TargetMol Bioactive Compound Library
Tocris Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
30
Molecular Weight
384.18
Hydrogen Bond Acceptors
7
Hydrogen Bond Donors
1
Rotatable Bonds
4
Ring Count
5
Aromatic Ring Count
0
cLogP
2.6
TPSA
100.52
Fraction CSP3
0.89
Chiral centers
8.0
Largest ring
7.0
QED
0.58
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
JAK/STAT Signaling
Stem Cells
Anti-infection
Apoptosis
Stem Cell/Wnt
Target
STAT
Ferroptosis
Parasite
Virus Protease
Primary Target
Inflammasomes
MOA
Stat inhibitor
Inhibitor
DNA synthesis inhibitor
Indication
malaria
Biosynthetic Origin
Terpenoid
Therapeutic Indication
Antiparasitic
Therapeutic Class
Antimicrobial
Source data
