General
Preferred name
BENZNIDAZOLE
Synonyms
Radanil ()
Ro 71051 ()
Ro 07-1051 ()
Benznidazol ()
Rochagan ()
Benznidazolum ()
Benzonidazol ()
RO-7-1051 ()
RO 07-1051 ()
RO-07-1051 ()
NSC-299972 ()
P&D ID
PD014256
CAS
22994-85-0
Tags
available
drug
Approved by
FDA
First approval
2017
Drug Status
approved
investigational
Max Phase
4.0
Drug indication
American trypanosomiasis
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Benznidazole (Ro 07-1051) is an antiparasitic medication, with an IC50 of 20.35 ¦ÌM for Colombian T. cruzi strains, and has been used in the treatment of Chagas disease[1][2].
PRICE
29
DESCRIPTION
Benznidazole is a nitroimidazole derivative having an antiprotozoal activity. Benznidazole is an antiparasitic medication for trypanosoma cruzi strains, and has been used in the treatment of Chagas disease.
(Enamine Bioactive Compounds)
DESCRIPTION
Benznidazol (Benznidazole)e has an antiprotozoal activity by interfering with parasite protein biosynthesis, influencing cytokines production and stimulating host phagocytosis.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
4
Organisms
7
Compound Sets
18
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMatrix
Enamine Bioactive Compounds
Enamine BioReference Compounds
MedChem Express Bioactive Compound Library
NCATS Inxight Approved Drugs
NPC Screening Collection
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Pathogen Box
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
36
Molecular Weight
260.09
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
1
Rotatable Bonds
5
Ring Count
2
Aromatic Ring Count
2
cLogP
1.11
TPSA
90.06
Fraction CSP3
0.17
Chiral centers
0.0
Largest ring
6.0
QED
0.64
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Disease
REFERENCE COMPOUNDS
Target
antiprotozoal
Parasite
antibiotic
MOA
Antibiotic
DNA synthesis inhibitor
Indication
Chagas disease
Pathway
Microbiology/virology
Anti-infection
Source data
