General
Preferred name
MITIGLINIDE
Synonyms
KAD-1229 calcium hydrate ()
S-21403 calcium hydrate ()
Mitiglinide (calcium hydrate) ()
KAD-1229 ()
S21403 ()
Mitiglinide calcium hydrate ()
Mitiglinide calcium ()
Mitiglinide (Calcium) ()
KAD-1229 (anhydrous) ()
S21403 (anhydrous) ()
Mitiglinide (calcium salt) ()
P&D ID
PD014248
CAS
207844-01-7
145525-41-3
145375-43-5
Tags
available
drug
Approved by
PMDA
First approval
2011
Drug indication
Diabetic complication
Drug Status
investigational
approved
Max Phase
Phase 3
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Mitiglinide Calcium is a blood glucose-lowering drugs, stimulating insulin secretion by closing the ATP-sensitive K+ channels in pancreatic beta-cells.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
16
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
Mcule NIBR MoA Box Subset
MedChem Express Bioactive Compound Library
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Other bioactive compounds
ReFrame library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
57
Molecular Weight
315.18
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
1
Rotatable Bonds
5
Ring Count
3
Aromatic Ring Count
1
cLogP
2.97
TPSA
57.61
Fraction CSP3
0.58
Chiral centers
3.0
Largest ring
6.0
QED
0.91
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Potassium Channel
ABCC8, KCNJ10, PPARG
Pathway
Membrane Transporter/Ion Channel
Member status
member
MOA
Insulin Secretagogues
insulin secretagogue
Indication
diabetes mellitus
Therapeutic Class
Hypoglycemic Agents
Source data
