General
Preferred name
AMYLMETACRESOL
Synonyms
Amylmetacresolum ()
5-Methyl-2-Pentylphenol ()
Throaties ()
6-n-amyl-m-cresol ()
P&D ID
PD014224
CAS
1300-94-3
Tags
available
drug
Drug Status
approved
Max Phase
Phase 4
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PHARMACODYNAMICS The mixture of amylmetacresol throat lozenge medications markedly reduces the infectivity of certain infectious viruses in the throat and in cough droplets, thus reducing opportunities for person-to-person transmission [L2571]. In addition, it relieves symptoms of sore throat/irritation of the throat [A32773], [A32774].; ; Amylmetacresol is thought to inhibit the inflammatory and pain mediators that are involved in the inflammation of the mouth and throat mucous membranes, as well as the sore throat [L2573].
MOA The mechanism of virucidal action is not fully elucidated, however it is suggested that denaturation of external protein spikes, a pH-induced rearrangement of the tertiary structure of attachment proteins, or a selective effect on viral lipid membranes/protein–lipid interaction is responsible for this action [A32778].; ; Amylmetacresol is an antibacterial and antiviral agent, and blocks voltage-gated Na channels in a local anesthetic-like manner [A32780].
TOXICITY Oral LD50: 1500 mg/kg (rat) [MSDS]; ; Adverse effects include hypersensitivity reactions, tongue soreness [L2570].; ; Occasionally, hypersensitivity reactions may occur, manifested by digestive problems such as nausea or dyspepsia. This is extremely rare [L2571].; ; In the case of overdose, management should be symptomatic. In cases of severe overdosage, gastric lavage may be warranted to empty the stomach contents. Saline laxatives and activated charcoal may be administered orally [L2570].
Compound Sets
9
ChEMBL Approved Drugs
CHEMBL1512677
ChEMBL Drugs
CHEMBL1512677
DrugBank
DB13908
DrugBank Approved Drugs
DB13908
MedChem Express Bioactive Compound Library
HY-121527
NPC Screening Collection
ReFrame library
Selleckchem Bioactive Compound Library
amylmetacresol
TargetMol Bioactive Compound Library
T4557
External IDs
22
Properties
(calculated by RDKit )
Molecular Weight
178.14
Hydrogen Bond Acceptors
1
Hydrogen Bond Donors
1
Rotatable Bonds
4
Ring Count
1
Aromatic Ring Count
1
cLogP
3.43
TPSA
20.23
Fraction CSP3
0.5
Chiral centers
0.0
Largest ring
6.0
QED
0.7
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Pathway
Anti-infection
Target
HIV
Source data