General
Preferred name
VALRUBICIN
Synonyms
Valstar ()
AD-32 ()
NSC-246131 ()
Valstar preservative free ()
Valrubicine ()
AD 32 ()
Valrubicina ()
P&D ID
PD014197
CAS
56124-62-0
Tags
available
drug
Approved by
FDA
First approval
1998
Drug indication
Bladder cancer
Psoriasis vulgaris
Neoplasm
Drug Status
approved
Max Phase
4.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PHARMACODYNAMICS
Valrubicin is an anticancer agent.
DESCRIPTION
Valrubicin is a chemotherapy agent, inhibits TPA- and PDBu-induced PKC activation with IC50s of 0.85 and 1.25 ¦ÌM, respectively, and has antitumor and antiinflammatory activity.
PRICE
175
DESCRIPTION
Valrubicin (AD-32) (AD 32) inhibits TPA- and PDBu-induced PKC activation (IC50s: 0.85 and 1.25 ??M) and has antitumor and anti-inflammatory activity.
DESCRIPTION
Valrubicin (AD-32) (AD 32) inhibits TPA- and PDBu-induced PKC activation (IC50s: 0.85 and 1.25 μM) and has antitumor and anti-inflammatory activity.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
18
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
JUMP-MOA Compound Set
MedChem Express Bioactive Compound Library
NCATS Inxight Approved Drugs
NPC Screening Collection
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
36
Molecular Weight
723.21
Hydrogen Bond Acceptors
13
Hydrogen Bond Donors
5
Rotatable Bonds
10
Ring Count
5
Aromatic Ring Count
2
cLogP
2.46
TPSA
215.22
Fraction CSP3
0.5
Chiral centers
6.0
Largest ring
6.0
QED
0.15
Structural alerts
1
quinone_A(370)
[!#6&!#1]=[#6]1[#6]=,:[#6][#6](=[!#6&!#1])[#6]=,:[#6]1
PAINS Family A
Related compounds
Custom attributes
(extracted from source data)
Target
antibiotic
PKC
TOP2A
MOA
DNA inhibitor, topoisomerase inhibitor
DNA inhibitor
Indication
bladder cancer
Pathway
Chromatin/Epigenetic
Cytoskeletal Signaling
Microbiology/virology
Anti-infection
Epigenetics
TGF-beta/Smad
Therapeutic Class
Anticancer Agents
Source data
