General
Preferred name
BERAPROST
Synonyms
Dorner ()
BERAPROST SODIUM ()
Beraprost (sodium) ()
TRK-100 ()
ML 1129 (sodium) ()
TRK-100STP FREE ACID ()
MDL-201229 ()
ML-1229 ()
ML-1129 ()
MDL-201129 ()
Procylin ()
TRK-100STP ()
Beraprost sodium salt ()
P&D ID
PD014175
CAS
88430-50-6
88475-69-8
496807-11-5
Tags
available
drug
drug candidate
First approval
1992
Drug Status
approved
investigational
Max Phase
3.0
Drug indication
Pulmonary arterial hypertension
Recurrent thrombophlebitis
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Beraprost sodium (TRK-100), a prostacyclin analog, is a stable and orally active proagent of PGI2. Beraprost sodium (TRK-100) is a potent vasodilator, has the potential for pulmonary arterial hypertension treatment through expanding renal vessels, improving microcirculation[1]. Beraprost sodium (TRK-100) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
DESCRIPTION
Beraprost is a synthetic analogue of prostacyclin, under clinical trials for the treatment of pulmonary hypertension. Beraprost acts by binding to prostacyclin membrane receptors ultimately inhibiting the release of Ca2+ from intracellular storage sites. Beraprost sodium (beraprost) is a stable, orally active prostacyclin analogue with vasodilatory, antiplatelet and cytoprotective effects.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
1
Compound Sets
8
BOC Sciences Bioactive Compounds
ChEMBL Drugs
DrugBank
DrugCentral
DrugCentral Approved Drugs
MedChem Express Bioactive Compound Library
Natural product-based probes and drugs
NPC Screening Collection
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
42
Molecular Weight
398.21
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
3
Rotatable Bonds
8
Ring Count
3
Aromatic Ring Count
1
cLogP
3.29
TPSA
86.99
Fraction CSP3
0.54
Chiral centers
6.0
Largest ring
6.0
QED
0.46
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Biosynthetic Origin
Fatty Acid (Eicosanoid)
Therapeutic Indication
Platelet Aggregation Inhibitor
Therapeutic Class
Cardiovascular
Target
Prostaglandin Receptor
Pathway
GPCR/G protein
Source data
