General
Preferred name
SPIRAMIDE
Synonyms
Spiramide hydrochloride ()
AMI-193 ()
ESPIRAMIDA ()
R 5808 ()
R-5808 ()
P&D ID
PD014121
CAS
510-74-7
3824-91-7
Tags
drug candidate
available
Drug indication
Discovery agent
Drug Status
investigational
Max Phase
2.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Spiramide (AMI-193) is a potent and selective antagonist of 5-HT2 and dopamine D2 receptor, with Kis of 2 nM and 3 nM, respectively. Spiramide has >2000-fold selectivity for 5-HT2 versus 5-HT1C (Ki=4300 nM) receptors. Spiramide exhibits antipsychotic activity[1][2][3].
PRICE 48
DESCRIPTION AMI-193 has been found to be a selective 5-HT antagonist and could be also used as a starting reagent in some pharmaceutical synthesis. (BOC Sciences Bioactive Compounds)
DESCRIPTION AMI-193 (Spiramide) is an effective and selective antagonist of 5-HT2 and D2 receptor with Kis of 2, 3, 50, 2530, and 4300 nM for 5-HT2, D2 Receptor, 5-HT1A, D1 Receptor, and 5-HT1C Receptor. AMI-193 shows antipsychotic activity. (TargetMol Bioactive Compound Library)
Compound Sets
11
BOC Sciences Bioactive Compounds
ami-193-cas-510-74-7-item-24421
Cayman Chemical Bioactives
43100
ChEMBL Drugs
CHEMBL79834
DrugMAP
DM5KNMD
DrugMatrix
EUbOPEN Chemogenomics Library
EUB0000444
Guide to Pharmacology
175
Ki Database
AMI-193
MedChem Express Bioactive Compound Library
HY-100971
NPC Screening Collection
TargetMol Bioactive Compound Library
T21855
External IDs
27
Properties
(calculated by RDKit )
Molecular Weight
383.2
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
1
Rotatable Bonds
6
Ring Count
4
Aromatic Ring Count
2
cLogP
3.02
TPSA
44.81
Fraction CSP3
0.41
Chiral centers
0.0
Largest ring
6.0
QED
0.78
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
5-HT2
D2 receptor
5-HT Receptor
Dopamine Receptor
Pathway
GPCR/G protein
Neuronal Signaling
Neuroscience
Recommended Cell Concentration
10 nM
Source data