General
Preferred name
MELITRACEN
Synonyms
Trausabun ()
Thymeol hydrochloride ()
Melixeran ()
MELITRACEN HYDROCHLORIDE ()
Melitracen (hydrochloride) ()
Adelax ()
Melitraceno ()
Melitracene ()
U 24973A ()
NSC-78229 ()
Melitracen hcl ()
U-24,973A ()
U-24973A ()
U 24,973A ()
Melitracen (hydrochloride) ()
P&D ID
PD014108
CAS
5118-29-6
10563-70-9
Tags
available
drug candidate
drug
Drug Status
approved
experimental
investigational
Max Phase
3.0
Drug indication
Major depressive disorder
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Melitracen hydrochloride is an orally active biphasic antidepressant and antianxiety agent. Melitracen hydrochloride can inhibit the uptake of Norepinephrine and 5-HT (serotonin) through the presynaptic membrane inducing the increase of monoamine transmitters in synaptic space[1][2].
PRICE 32
DESCRIPTION Melitracen hydrochloride is a potential dopamine D1/2 receptor antagonist. It has been used in combination with flupentixol in depression therapy. (BOC Sciences Bioactive Compounds)
DESCRIPTION Melitracen hydrochloride (Thymeol hydrochloride) , an antidepressant, is used as potential dopamine D1/2 receptor antagonist to treat depression. (TargetMol Bioactive Compound Library)
Compound Sets
12
BOC Sciences Bioactive Compounds
melitracen-hydrochloride-cas-10563-70-9-item-8811
Cayman Chemical Bioactives
40117
ChEMBL Drugs
CHEMBL110094
CHEMBL2107109
DrugBank
DB13384
DrugCentral
1675
DrugCentral Approved Drugs
1675
DrugMatrix
MedChem Express Bioactive Compound Library
HY-108256
NPC Screening Collection
ReFrame library
Selleckchem Bioactive Compound Library
melitracen-hydrochloride
TargetMol Bioactive Compound Library
T4274
External IDs
41
Properties
(calculated by RDKit )
Molecular Weight
291.2
Hydrogen Bond Acceptors
1
Hydrogen Bond Donors
0
Rotatable Bonds
3
Ring Count
3
Aromatic Ring Count
2
cLogP
4.71
TPSA
3.24
Fraction CSP3
0.33
Chiral centers
0.0
Largest ring
6.0
QED
0.79
Structural alerts
1
styrene_B(8)
c:1:c:c-2:c(:c:c:1)-[#6](-c:3:c(-[$([#16;X2]),$([#6;X4])]-2):c:c:[c;!H0,$(c-[#17]),$(c-[#6;X4])](:c:3))=[#6]-[#6]
PAINS Family C
Related compounds
Custom attributes
(extracted from source data)
Target
5-HT Receptor
D1
D2
MOA
Dopamine Receptor
Pathway
GPCR/G protein
Neuronal Signaling
Neuroscience
Source data