General
Preferred name
CHLORISONDAMINE
Synonyms
Chlorisondamine chloride ()
Chlorisondamine diiodide ()
CHLORISONDAMINE DICHLORIDE ()
Chlorisondamine (diiodide) ()
Chlorisondamine (iodide) ()
Chlorisondamine cation ()
Chlorisondamine ion ()
Cloruro de clorisondamina ()
Chlorure de chlorisondamine ()
P&D ID
PD014047
CAS
96750-66-2
7701-62-4
69-27-2
303-92-4
Tags
available
drug candidate
drug
Drug Status
approved
investigational
Max Phase
2.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Chlorisondamine (diiodide) is a potent nicotinic acetylcholine receptor (nAChR) antagonist and a ganglion blocker. Chlorisondamine antagonizes some of nicotine's central actions in a potent, long-lasting and pharmacologically selective way[1].
DESCRIPTION
Na+ channel blocker
(Tocris Bioactive Compound Library)
DESCRIPTION
Nicotinic antagonist; slow offset
(Tocriscreen Total)
DESCRIPTION
Chlorisondamine diiodide is an exceptionally long-lasting and irreversible nicotinic acetylcholine receptor antagonist with IC50 value of 1.6 mM. It blocks central nicotinic responses and can persist for several weeks. It is used as an intracranial injection to study the analysis and localization of small drug molecules in rat brain tissue.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
15
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMatrix
Ki Database
MedChem Express Bioactive Compound Library
NPC Screening Collection
ReFrame library
Tocris Bioactive Compound Library
Tocriscreen Total
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
36
Molecular Weight
356.04
Hydrogen Bond Acceptors
0
Hydrogen Bond Donors
0
Rotatable Bonds
3
Ring Count
2
Aromatic Ring Count
1
cLogP
4.47
TPSA
0.0
Fraction CSP3
0.57
Chiral centers
0.0
Largest ring
6.0
QED
0.43
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Primary Target
Nicotinic Receptors (Non-selective)
MOA
Antagonist
acetylcholine receptor antagonist
Target
CHRNA1
nAChR
Pathway
Membrane Transporter/Ion Channel
Neuronal Signaling
Source data
