General
Preferred name
TELITHROMYCIN
Synonyms
HMR3647 ()
RU66647 ()
Telitromicina ()
HMR 3647 ()
Telithromycine ()
Levviax ()
Ketek ()
HMR-3647 ()
NSC-758940 ()
P&D ID
PD014042
CAS
173838-31-8
191114-48-4
Tags
available
drug
Approved by
FDA
First approval
2004
2001
Drug indication
infection
Bacterial infection
Drug Status
approved
withdrawn
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Telithromycin (HMR3647) is a novel ketolide antibiotic that structurally resembles macrolides. Telithromycin belongs to the ketolide family that is characterized by a keto group at position 3 of the macrolide ring and is active against bacteria causing community-acquired pneumonia, acute exacerbation of chronic bronchitis, and acute sinusitis. Telithromycin also has similar immunomodulatory effects as macrolides. Telithromycin can be used for the research of respiratory infections including bronchial asthma[1][2].
Cell lines
0
Organisms
1
Compound Sets
13
ChEMBL Approved Drugs
CHEMBL1136
ChEMBL Drugs
CHEMBL1136
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB00976
DrugBank Approved Drugs
DB00976
DrugCentral
2581
DrugCentral Approved Drugs
2581
DrugMAP
DMZ4P3A
DrugMAP Approved Drugs
DMZ4P3A
MedChem Express Bioactive Compound Library
HY-A0062
NPC Screening Collection
Withdrawn 2.0
EMA42
External IDs
37
Properties
(calculated by RDKit )
Molecular Weight
811.47
Hydrogen Bond Acceptors
14
Hydrogen Bond Donors
1
Rotatable Bonds
11
Ring Count
5
Aromatic Ring Count
2
cLogP
4.93
TPSA
171.85
Fraction CSP3
0.72
Chiral centers
13.0
Largest ring
14.0
QED
0.18
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
CYP1A2, CYP2D6, CYP3A4, CYP3A5, CYP3A7
antibiotic
Bacterial
MOA
bacterial 30S ribosomal subunit inhibitor, bacterial 50S ribosomal subunit inhibitor
Indication
pneumonia
ATC
J01FA15
Therapeutic Class
Antibiotics
Pathway
Anti-infection
Source data