General
Preferred name
quinpirole
Synonyms
(-)-Quinpirole hydrochloride ()
(±)-Quinpirole dihydrochloride ()
Quinpirole (hydrochloride) ()
QUINPIROLE HYDROCHLORIDE ()
LY 171555 (hydrochloride) ()
Quinpirole hcl ()
LY171555 ()
LY-171555 ()
P&D ID
PD014039
CAS
85798-08-9
80373-22-4
74196-94-4
85760-74-3
Tags
available
drug candidate
Drug indication
Discovery agent
Antihypertensive
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
A2A agonist
(Tocris Bioactive Compound Library)
DESCRIPTION
Selective D2-like agonist
(Tocriscreen Plus)
DESCRIPTION
Selective D2-like dopamine receptor agonist with some selectivity for D3 sites
(LOPAC library)
DESCRIPTION
Selective D2-like agonist
(Tocriscreen Total)
DESCRIPTION
(-)-Quinpirole hydrochloride is a selective dopamine D2 receptor agonist, with high affinity for the D2 and D3 dopamine receptor subtypes (Ki values are 4.8, ~24, ~30 and 1900 nM at D2, D3, D4 and D1 receptors respectively).
(BOC Sciences Bioactive Compounds)
DESCRIPTION
Selective D2-like dopamine receptor agonist which possesses some activity at D3 dopamine receptors
(LOPAC library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
2
Compound Sets
16
BOC Sciences Bioactive Compounds
ChEMBL Drugs
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
Drug Repurposing Hub
DrugMAP
Guide to Pharmacology
LOPAC library
MedChem Express Bioactive Compound Library
NPC Screening Collection
ReFrame library
Tocris Bioactive Compound Library
Tocriscreen Plus
Tocriscreen Total
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
45
Molecular Weight
219.17
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
1
Rotatable Bonds
2
Ring Count
3
Aromatic Ring Count
1
cLogP
2.0
TPSA
31.92
Fraction CSP3
0.77
Chiral centers
2.0
Largest ring
6.0
QED
0.82
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
7-TM Receptors
Selectivity
D2 > D3
D2/D3
Primary Target
Non-selective Dopamine
MOA
Agonist
Dopamine Receptor agonist
Target
DRD1, DRD2, DRD3, DRD4, HTR1A, HTR2A, HTR2B, HTR2C
Dopamine Receptor
Pathway
GPCR/G protein
Neuronal Signaling
Source data
