General
Preferred name
SR-57227
Synonyms
Sr 57227a ()
SR 57227 hydrochloride ()
SR 57227A77145-61-0 ()
SR 57227A hydrochloride ()
SR57227A ()
SR 57227A (hydrochloride) ()
P&D ID
PD014014
CAS
77145-61-0
77145-51-8
Tags
drug candidate
natural product
available
Drug indication
Major depressive disorder
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Inhibits AMPA desensitization
(Tocris Bioactive Compound Library)
DESCRIPTION
Potent and selective 5-HT3 serotonin receptor agonist.
(LOPAC library)
DESCRIPTION
Potent, selective 5-HT3 agonist
(Tocriscreen Total)
DESCRIPTION
SR 57227 hydrochloride is a selective and high affinity 5-HT3 receptor agonist. SR 57227 exhibits anti-depressant like effects and decreases isolation-induced aggressive behavior in rat model.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
19
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
Drug Repurposing Hub
DrugMAP
Guide to Pharmacology
LOPAC library
Mcule NIBR MoA Box Subset
MedChem Express Bioactive Compound Library
NIH Clinical Collections (NCC)
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
ReFrame library
TargetMol Bioactive Compound Library
Tocris Bioactive Compound Library
Tocriscreen Total
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
32
Molecular Weight
211.09
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
1
Rotatable Bonds
1
Ring Count
2
Aromatic Ring Count
1
cLogP
1.66
TPSA
42.15
Fraction CSP3
0.5
Chiral centers
0.0
Largest ring
6.0
QED
0.72
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
5-HT3
Pathway
GPCR/G protein
Neuroscience
Neuronal Signaling
Primary Target
5-HT3 Receptors
MOA
Agonist
Selective HTR3 agonist
serotonin receptor agonist
Member status
member
Target
HTR3A
5-HT Receptor
Source data
