General
Preferred name
EPRISTERIDE
Synonyms
SKF105657 ()
ONO-9302 ()
ONO9302 ()
Epristerida ()
SK&F 105657 ()
SK&F-105657 ()
P&D ID
PD014001
CAS
119169-78-7
Tags
available
drug candidate
Drug indication
Hirsutism
Drug Status
investigational
Max Phase
2.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Epristeride (ONO-9302) is a selective, specific and orally active uncompetitive inhibitor of human steroid 5 alpha-reductase isoform 2. Epristeride has inhibitory effects for SR isoenzymes types 2 with Ki value of 0.7-2 nM. Epristeride can be used for the research of prostatic hyperplasia and acne[1].
PRICE 336
DESCRIPTION Epristeride (ONO-9302) is an orally active, selective and non-competitive steroidal 5-??-reductase isoform 2 inhibitor that inhibits SR isoform 2.Episteride reduces prostate size and improves symptoms in men with BPH.Episteride induces atrophy and apoptosis of the ventral prostate in rats.
DESCRIPTION Epristeride (ONO-9302) is an orally active, selective and non-competitive steroidal 5-α-reductase isoform 2 inhibitor that inhibits SR isoform 2.Episteride reduces prostate size and improves symptoms in men with BPH.Episteride induces atrophy and apoptosis of the ventral prostate in rats. (TargetMol Bioactive Compound Library)
Compound Sets
7
ChEMBL Drugs
CHEMBL138225
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugMAP
DM35T1O
MedChem Express Bioactive Compound Library
HY-107385
NPC Screening Collection
TargetMol Bioactive Compound Library
T15239
External IDs
28
Properties
(calculated by RDKit )
Molecular Weight
399.28
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
2
Rotatable Bonds
2
Ring Count
4
Aromatic Ring Count
0
cLogP
5.1
TPSA
66.4
Fraction CSP3
0.76
Chiral centers
6.0
Largest ring
6.0
QED
0.68
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Apoptosis
5-α reductase
5 alpha Reductase
MOA
5 alpha reductase inhibitor
Pathway
Metabolic Enzyme/Protease
Endocrinology/Hormones
Metabolism
Source data