General
Preferred name
BRODIMOPRIM
Synonyms
Ro 10-5970 ()
Brodimoprime ()
Brodimoprima ()
P&D ID
PD013980
CAS
56518-41-3
Tags
available
drug
First approval
1993
Drug Status
investigational
approved
experimental
Max Phase
2.0
Drug indication
bacterial disease
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Brodimoprim (Ro 10-5970), a trimethoprim analogue, is an orally active dihydrofolate reductase inhibitor. Brodimoprim is highly active against a broad spectrum of gram-negative and gram-positive bacteria[1].
PRICE 98
DESCRIPTION Brodimoprim belongs to the diaminopyrimidine class of compounds and is a structural analogue of . It inhibits bacterial dihydrofolate reductase (DHFR) and has antibacterial and antiprotozoal activities . (GtoPdb)
DESCRIPTION Brodimoprim is an inhibitor of dihydrofolate reductase(DHFR). Brodimoprim is also a long-acting broad-spectrum antibacterial agent characterized by a good pharmacokinetic profile. (TargetMol Bioactive Compound Library)
Compound Sets
11
ChEMBL Drugs
CHEMBL31891
CZ-OPENSCREEN Bioactive Library
DrugBank
DB13795
DrugCentral
398
DrugCentral Approved Drugs
398
DrugMatrix
Guide to Pharmacology
12325
MedChem Express Bioactive Compound Library
HY-121341
NPC Screening Collection
ReFrame library
TargetMol Bioactive Compound Library
T19858
External IDs
25
Properties
(calculated by RDKit )
Molecular Weight
338.04
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
2
Rotatable Bonds
4
Ring Count
2
Aromatic Ring Count
2
cLogP
2.01
TPSA
96.28
Fraction CSP3
0.23
Chiral centers
0.0
Largest ring
6.0
QED
0.88
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
Bacterial
DHFR
Pathway
Anti-infection
Cell Cycle/Checkpoint
DNA Damage/DNA Repair
Metabolism
Microbiology/virology
Source data