General
Preferred name
ATIPAMEZOLE
Synonyms
Atipamezole hydrochloride ()
Mpv 1248 ()
MPV-1248 hydrochloride ()
Antisedan ()
Atipamezole HCl ()
Atipamezole (hydrochloride) ()
MPV-1248, MPV1248, MPV 1248, Antisedan ()
Antisedan, MPV-1248 hydrochloride, MPV1248 hydrochloride, MPV 1248 hydrochloride ()
MPV-1248 ()
4-(2-ethyl-2-indanyl)imidazole. ()
Atipamezole (hydrochloride) ()
P&D ID
PD013951
CAS
104075-48-1
104054-27-5
Tags
available
drug
Drug Status
investigational
approved
vet_approved
Approved by
FDA
Drug indication
Male sexual disorder
Antagonist (alpha2-receptor)
Max Phase
Phase 1
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Atipamezole is an α2-adrenoceptor antagonist. It is used as a veterinary drug to reverse the sedative and analgesic effects of α2-adrenoceptor agonists ( and medetomidine) in dogs. (GtoPdb)
DESCRIPTION Highly selective, orally active ETA antagonist (Tocris Bioactive Compound Library)
DESCRIPTION Selective alpha2 antagonist (Tocriscreen Plus)
Compound Sets
21
AdooQ Bioactive Compound Library
A13902
Axon Medchem Screening Library
1371
Cayman Chemical Bioactives
9001181
34289
ChEMBL Drugs
CHEMBL353972
Concise Guide to Pharmacology 2023/24
12576
Drug Repurposing Hub
DrugBank
DB11481
DrugBank Approved Drugs
DB11481
DrugCentral
5574
DrugMAP
DM10XWU
DrugMatrix
Guide to Pharmacology
12576
Ki Database
ATIPAMEZOLE
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL353972
MedChem Express Bioactive Compound Library
HY-12380
HY-12380A
NPC Screening Collection
ReFrame library
Selleckchem Bioactive Compound Library
atipamezole-hydrochloride
atipamezole
TargetMol Bioactive Compound Library
T6765
Tocris Bioactive Compound Library
2937
Tocriscreen Plus
2937
External IDs
46
Properties
(calculated by RDKit )
Molecular Weight
212.13
Hydrogen Bond Acceptors
1
Hydrogen Bond Donors
1
Rotatable Bonds
2
Ring Count
3
Aromatic Ring Count
2
cLogP
2.86
TPSA
28.68
Fraction CSP3
0.36
Chiral centers
0.0
Largest ring
6.0
QED
0.81
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
7-TM Receptors
Pathway
GPCR/G protein
Neuroscience
Neuronal Signaling
Target
??2-adrenoceptor antagonist
¦Á2-adrenoceptor
a2 antagonist
Adrenergic Receptor
Primary Target
Adrenergic ?2 Receptors
MOA
Antagonist
Adrenergic Receptor antagonist
Indication
reverse sedative
Source data