General
Preferred name
IMILOXAN
Synonyms
IMILOXAN HYDROCHLORIDE ()
RS-21361 ()
RS 21361 ()
RS21361 ()
Imiloxan (hydrochloride) ()
Imiloxan hcl ()
GNF-Pf-2156 ()
P&D ID
PD013942
CAS
81167-22-8
81167-16-0
86710-23-8
Tags
available
drug candidate
Drug indication
Discovery agent
Drug Status
investigational
Max Phase
2.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE 965
DESCRIPTION Imiloxan (RS-21361) is an ??2 adrenergic receptor antagonist used in the treatment of major depressive disorder.
DESCRIPTION Imiloxan hydrochloride is a potent and selective alpha 2B-adrenoceptor antagonist. Imiloxan hydrochloride has the potential for acute kidney injury research[1][2].
DESCRIPTION Imiloxan (RS-21361) is an α2 adrenergic receptor antagonist used in the treatment of major depressive disorder. (TargetMol Bioactive Compound Library)
DESCRIPTION Potent and selective alpha2 antagonist (Tocris Bioactive Compound Library)
DESCRIPTION Selective alpha2B-adrenoceptor antagonist (LOPAC library)
DESCRIPTION Highly selective α2B antagonist (Tocriscreen Total)
Cell lines
0
Organisms
1
Compound Sets
16
ChEMBL Drugs
CHEMBL347695
CHEMBL578481
Concise Guide to Pharmacology 2017/18
3470
Concise Guide to Pharmacology 2019/20
3470
Concise Guide to Pharmacology 2021/22
3470
Concise Guide to Pharmacology 2023/24
3470
DrugMAP
DMS4D96
DrugMatrix
Guide to Pharmacology
3470
Ki Database
IMILOXAN
LOPAC library
MedChem Express Bioactive Compound Library
HY-101337A
NPC Screening Collection
ReFrame library
TargetMol Bioactive Compound Library
T27599
Tocris Bioactive Compound Library
0986
Tocriscreen Total
External IDs
36
Properties
(calculated by RDKit )
Molecular Weight
244.12
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
0
Rotatable Bonds
3
Ring Count
3
Aromatic Ring Count
2
cLogP
2.29
TPSA
36.28
Fraction CSP3
0.36
Chiral centers
1.0
Largest ring
6.0
QED
0.83
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
alpha2B
Target
α2 adrenergic receptor
Adrenergic Receptor
Primary Target
Adrenergic ?2 Receptors
MOA
Antagonist
Pathway
GPCR/G protein
Neuroscience
Neuronal Signaling
Source data