General
Preferred name
MEFLOQUINE
Synonyms
Mefloquin hydrochloride ()
Mefloquine HCl ()
MEFLOQUINE HYDROCHLORIDE ()
Fansimef-mefloquine ()
Mefloquine hydrochloride51773-92-3 ()
Mefloquine (hydrochloride) ()
(S,R)-MEFLOQUINE ()
P&D ID
PD013894
CAS
51773-92-3
53230-10-7
51742-87-1
147368-41-0
Tags
available
drug
Approved by
FDA
First approval
1989
Drug Status
approved
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION The approved drug mefloquine is a racemic mixture of (R,S)- and (S,R)-enantiomers. Note that the ChEMBL link is to the non-stereoisomeric form of the molecule. PubChem lists 9 stereoisotopes. The administerd form contains the mefloquine hydrochloride salt.

Mefloquine is one of the key antimalarials listed in the WHO 20th Essential Medicines List (2017).
DESCRIPTION The approved drug mefloquine is a racemic mixture of (R,S)- and (S,R)-enantiomers. Note that the ChEMBL link is to the non-stereoisomeric form of the molecule. PubChem lists 9 stereoisotopes.
DESCRIPTION Suppresses ROS-induced activation of the NLRP3 inflammasome; antimalarial (Tocris Bioactive Compound Library)
Cell lines
3
Organisms
8
Compound Sets
17
AdooQ Bioactive Compound Library
A14237
Cayman Chemical Bioactives
23665
Concise Guide to Pharmacology 2017/18
4252
Drug Repurposing Hub
DrugCentral
1665
DrugCentral Approved Drugs
1665
MedChem Express Bioactive Compound Library
HY-17437A
Natural product-based probes and drugs
NCATS Inxight Approved Drugs
TML814419R
NIH Clinical Collections (NCC)
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
ReFrame library
Selleckchem Bioactive Compound Library
mefloquine-hcl
TargetMol Bioactive Compound Library
T0860
The Pathogen Box
Tocris Bioactive Compound Library
6819
External IDs
44
Properties
(calculated by RDKit )
Molecular Weight
378.12
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
2
Rotatable Bonds
2
Ring Count
3
Aromatic Ring Count
2
cLogP
4.45
TPSA
45.15
Fraction CSP3
0.47
Chiral centers
2.0
Largest ring
6.0
QED
0.76
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Disease
REFERENCE COMPOUNDS
Target
hemozoin
Parasite
Potassium Channel
ROS Kinase
SARS-CoV
Primary Target
Gap Channels
MOA
Others inhibitor
Blocker
Antimalarial
Pannexin 1 (PANX1) Inhibitors
adenosine receptor antagonist, hemoglobin antagonist
Member status
member
Indication
malaria
Biosynthetic Origin
Alkaloid
Therapeutic Indication
Antiparasitic
Therapeutic Class
Antimicrobial
Pathway
Anti-infection
Autophagy
Membrane Transporter/Ion Channel
Protein Tyrosine Kinase/RTK
Source data