General
Preferred name
MEFLOQUINE
Synonyms
Mefloquin hydrochloride ()
Mefloquine HCl ()
MEFLOQUINE HYDROCHLORIDE ()
Fansimef-mefloquine ()
Mefloquine hydrochloride51773-92-3 ()
Mefloquine (hydrochloride) ()
(S,R)-MEFLOQUINE ()
P&D ID
PD013894
CAS
51773-92-3
53230-10-7
51742-87-1
147368-41-0
Tags
available
drug
Approved by
FDA
First approval
1989
Drug Status
approved
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
The approved drug mefloquine is a racemic mixture of (R,S)- and (S,R)-enantiomers. Note that the ChEMBL link is to the non-stereoisomeric form of the molecule. PubChem lists 9 stereoisotopes. The administerd form contains the mefloquine hydrochloride salt.
Mefloquine is one of the key antimalarials listed in the WHO 20th Essential Medicines List (2017).
Mefloquine is one of the key antimalarials listed in the WHO 20th Essential Medicines List (2017).
DESCRIPTION
The approved drug mefloquine is a racemic mixture of (R,S)- and (S,R)-enantiomers. Note that the ChEMBL link is to the non-stereoisomeric form of the molecule. PubChem lists 9 stereoisotopes.
DESCRIPTION
Suppresses ROS-induced activation of the NLRP3 inflammasome; antimalarial
(Tocris Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
3
Organisms
8
Compound Sets
17
AdooQ Bioactive Compound Library
Cayman Chemical Bioactives
Concise Guide to Pharmacology 2017/18
Drug Repurposing Hub
DrugCentral
DrugCentral Approved Drugs
MedChem Express Bioactive Compound Library
Natural product-based probes and drugs
NCATS Inxight Approved Drugs
NIH Clinical Collections (NCC)
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Pathogen Box
Tocris Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
44
Properties
(calculated by RDKit )
Molecular Weight
378.12
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
2
Rotatable Bonds
2
Ring Count
3
Aromatic Ring Count
2
cLogP
4.45
TPSA
45.15
Fraction CSP3
0.47
Chiral centers
2.0
Largest ring
6.0
QED
0.76
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Disease
REFERENCE COMPOUNDS
Target
hemozoin
Parasite
Potassium Channel
ROS Kinase
SARS-CoV
Primary Target
Gap Channels
MOA
Others inhibitor
Blocker
Antimalarial
Pannexin 1 (PANX1) Inhibitors
adenosine receptor antagonist, hemoglobin antagonist
Member status
member
Indication
malaria
Biosynthetic Origin
Alkaloid
Therapeutic Indication
Antiparasitic
Therapeutic Class
Antimicrobial
Pathway
Anti-infection
Autophagy
Membrane Transporter/Ion Channel
Protein Tyrosine Kinase/RTK
Source data