General
Preferred name
BENDAZOL
Synonyms
2-Benzylbenzimidazole, Dibazol, Dibazole, Bendazole, Tromasedan ()
2-benzyl-1H-1,3-benzodiazole ()
NSC-60020 ()
2-Benzylbenzimidazole ()
P&D ID
PD013875
CAS
621-72-7
Tags
available
drug
Drug Status
approved
investigational
Max Phase
2.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Bendazol is an orally effective antihypertensive agent. Bendazol acts directly on vascular smooth muscle to dilate blood vessels and reduce peripheral resistance, thereby improving blood circulation. Bendazol significantly inhibits the development of myopia in rabbit models. Bendazol can regulate kidney function by increasing the activity of NO synthase in the rat model of nephrogenic hypertension. In addition, Bendazol has an effect on sexual behavior and spermatogenesis in male rats[1][2][3].
PRICE
29
DESCRIPTION
Bendazol (Dibazol) is always used as the drug for hypertension and cerebral Angiospasm.
DESCRIPTION
2-Benzylbenzimidazole shows inhibitory activity against glycogen phosphorylase.
(Enamine Bioactive Compounds)
DESCRIPTION
PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
9
ChEMBL Drugs
Drug Repurposing Hub
DrugCentral
DrugCentral Approved Drugs
Enamine Bioactive Compounds
MedChem Express Bioactive Compound Library
NPC Screening Collection
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
24
Molecular Weight
208.1
Hydrogen Bond Acceptors
1
Hydrogen Bond Donors
1
Rotatable Bonds
2
Ring Count
3
Aromatic Ring Count
3
cLogP
3.15
TPSA
28.68
Fraction CSP3
0.07
Chiral centers
0.0
Largest ring
6.0
QED
0.69
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
MOA
nitric oxide synthase stimulant
Target
HIF/HIF Prolyl-Hydroxylase
NO Synthase
HIF,NOS
Pathway
Immunology/Inflammation
Metabolic Enzyme/Protease
Source data
