General
Preferred name
METHYLPREDNISOLONE HEMISUCCINATE
Synonyms
methylprednisolone succinate ()
6¦Á-Methylprednisolone 21-hemisuccinate (sodium salt) ()
6??-Methylprednisolone 21-hemisuccinate (sodium salt) ()
U-9088, 6??-Methylprednisolone 21-hemisuccinate Sodium ()
Methylprednisolone succinate (sodium) ()
METHYLPREDNISOLONE SODIUM SUCCINATE ()
Methylprednisolone hydrogen succinate (sodium) ()
Methylprednisolone hydrogen succinate ()
U-9088, 6¦Á-Methylprednisolone 21-hemisuccinate Sodium ()
6α-Methylprednisolone 21-Hemisuccinate Sodium Salt ()
Methylprednisolone succinate ()
NSC-48989 ()
Solu-medrol ()
Min-I-Mix ()
Solu-Medrone ()
A-Methapred ()
Urbasone ()
Methylprednisolone 21-succinate sodium salt ()
Methylprednisolone ()
6.alpha.-Methylprednisolone 21-hemisuccinate ()
6?-Methylprednisolone 21-hemisuccinate (sodium salt) ()
P&D ID
PD013851
CAS
2921-57-5
2375-03-3
Tags
prodrug
natural product
drug
available
Approved by
FDA
First approval
1959
Drug Status
approved
Max Phase
Phase 4
Drug indication
Adrenocortical Steroid,Glucocorticoid
Glucocorticoid
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION 6α-Methylprednisolone 21-hemisuccinate, a derivative of prednisolone, is a kind of glucocorticoids. It has been developed for having longer half-life than that of Prednisolone and the potential anti-inflammatory effects. (BOC Sciences Bioactive Compounds)
Compound Sets
12
BOC Sciences Bioactive Compounds
6-methylprednisolone-21-hemisuccinate-sodium-cas-2375-03-3-63688
Cayman Chemical Bioactives
11800
35742
ChEMBL Approved Drugs
CHEMBL1201265
CHEMBL1201081
ChEMBL Drugs
CHEMBL1201265
CHEMBL1201081
Drug Repurposing Hub
DrugBank
DB14644
DrugBank Approved Drugs
DB14644
DrugCentral
1771
DrugCentral Approved Drugs
1771
MedChem Express Bioactive Compound Library
HY-B1900
HY-B1060
NPC Screening Collection
Selleckchem Bioactive Compound Library
methylprednisolone-hemisuccinate-s6588
methylprednisolone-sodium-succinate
External IDs
46
Properties
(calculated by RDKit )
Molecular Weight
474.23
Hydrogen Bond Acceptors
7
Hydrogen Bond Donors
3
Rotatable Bonds
6
Ring Count
4
Aromatic Ring Count
0
cLogP
2.22
TPSA
138.2
Fraction CSP3
0.69
Chiral centers
8.0
Largest ring
6.0
QED
0.5
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Disease Area
endocrinology, rheumatology, dermatology, pulmonary, allergy, infectious disease, ophthalmology, gastroenterology, hematology, neurology/psychiatry
Indication
hypercalcemia, thyroiditis, osteoarthritis, rheumatoid arthritis, seborrheic dermatitis, asthma, allergic rhinitis, shingles, conjunctivitis, ulcerative colitis, enteritis, anemia, multiple sclerosis, mycosis
MOA
Glucocorticoid Receptor agonist
Pathway
Anti-infection
Immunology/Inflammation
Vitamin D Related/Nuclear Receptor
Target
Bacterial
Glucocorticoid Receptor
Immunology & Inflammation related
Solubility
Soluble in DMSO (Slightly), Methanol (Slightly)
Source data