General
Preferred name
LEUCOVORIN
Synonyms
LEUCOVORIN CALCIUM ()
Folinic acid (calcium salt pentahydrate) ()
Leucovorin calcium salt pentahydrate ()
Folinic Acid Calcium Salt Pentahydrate ()
Folinic acid calcium salt ()
folinic acid ()
Leucovorin (calcium salt pentahydrate) ()
Calcium leucovorin ()
[3H]folinic acid ()
Folinic acid (calcium) ()
Leucovorin (calcium) ()
Calcium folinate ()
Leucovorin calcium, Folinic acid calcium salt, Wellcovorin ()
Leucovorin Calcium Pentahydrate ()
LEUCOVORIN SODIUM ()
DL-Folinic Acid (calcium salt) ()
Folinato calcico ()
Wellcovorin ()
Leucovorin calcium preservative free ()
Calcium folinate pentahydrate ()
Lederfolat ()
NSC-3590 ()
Leucovorin calcium component of folfox ()
Folinate de calcium ()
Anhydrous calcium folinate ()
Folic acid related compound a ()
[3H]folinic acid ()
5-formyltetrahydrofolic acid ()
5-formyltetrahydrofolate ()
Folinic Acid ()
Folinic acid disodium ()
SODIUM FOLINATE ()
Oncofolic ()
Disodium folinate ()
Leucovorin sodium ()
Folinic acid Calcium ()
P&D ID
PD013847
CAS
1492-18-8
121521-95-7
6035-45-6
58-05-9
Tags
available
drug
drug candidate
Approved by
PMDA
FDA
First approval
1952
Drug indication
Discovery agent
gastric cancer
gastric carcinoma
colorectal adenocarcinoma
Solid tumour/cancer
Colorectal cancer
Drug Status
approved
investigational
Max Phase
3.0
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE 29
DESCRIPTION Folinic acid calcium (Leucovorin Calcium) is the active metabolite of folic acid. Leucovorin is used principally as an antidote to folic acid antagonists.
DESCRIPTION Location of tritium is unknown. (GtoPdb)
DESCRIPTION Folinic acid (Leucovorin) is a biological folic acid and is generally administered along with Methotrexate (MTX) (HY-14519) as a rescue agent to decrease MTX-induced toxicity[1].
DESCRIPTION Leucovorin is a derivative of folic acid, which can be used to increase levels of folic acid under conditions favoring folic acid inhibition. (BOC Sciences Bioactive Compounds)
Cell lines
1
Organisms
0
Compound Sets
26
AdooQ Bioactive Compound Library
A11110
BOC Sciences Bioactive Compounds
leucovorin-calcium-pentahydrate-cas-6035-45-6-345964
Cayman Chemical Bioactives
20383
ChEMBL Approved Drugs
CHEMBL1201138
CHEMBL1679
ChEMBL Drugs
CHEMBL1201138
CHEMBL1679
CHEMBL3707260
Concise Guide to Pharmacology 2017/18
4816
6690
Concise Guide to Pharmacology 2019/20
4816
6690
Concise Guide to Pharmacology 2021/22
4816
6690
Concise Guide to Pharmacology 2023/24
4816
6690
DrugBank
DB00650
DrugBank Approved Drugs
DB00650
DrugCentral
1232
DrugCentral Approved Drugs
1232
DrugMAP
DMNWZJG
DME0XHN
DMUAZWG
DrugMAP Approved Drugs
DMNWZJG
DMUAZWG
Enamine BioReference Compounds
Guide to Pharmacology
4816
6690
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL1679
MedChem Express Bioactive Compound Library
HY-13664
HY-B0080
HY-17556
NCATS Inxight Approved Drugs
Q573I9DVLP
NPC Screening Collection
Other bioactive compounds
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
calcium-folinate
The Spectrum Collection
External IDs
144
Properties
(calculated by RDKit )
Molecular Weight
473.17
Hydrogen Bond Acceptors
9
Hydrogen Bond Donors
7
Rotatable Bonds
10
Ring Count
3
Aromatic Ring Count
2
cLogP
-0.73
TPSA
219.84
Fraction CSP3
0.3
Chiral centers
2.0
Largest ring
6.0
QED
0.21
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Antifolate
Folate Analogue
Endogenous Metabolite
DHFR
Pathway
Cell Cycle/DNA Damage
Metabolic Enzyme/Protease
MOA
DNA/RNA Synthesis inhibitor
Vitamin agonist
Therapeutic Class
Vitamins
Anticancer Agents
Source data