General
Preferred name
LEUCOVORIN
Synonyms
LEUCOVORIN CALCIUM ()
Folinic acid (calcium salt pentahydrate) ()
Leucovorin calcium salt pentahydrate ()
Folinic acid Calcium ()
Folinic acid calcium salt ()
Wellcovorin ()
Calcium folinate ()
Folinic Acid Calcium Salt Pentahydrate ()
folinic acid ()
Leucovorin (calcium salt pentahydrate) ()
Calcium leucovorin ()
[3H]folinic acid ()
Folinic acid (calcium) ()
SODIUM FOLINATE ()
Leucovorin (calcium) ()
Leucovorin (NSC -3590) Calcium Pentahydrate ()
Folinic acid,NSC-3590 Calcium Pentahydrate,Calcium, Calcium Folinatc, Citrovorum Factor ()
Leucovorin calcium, Folinic acid calcium salt, Wellcovorin ()
Leucovorin Calcium Pentahydrate ()
Anhydrous calcium folinate ()
Calcium folinate pentahydrate ()
Calcii folinas ()
Citrovorum Factor ()
Rescufolin ()
Rescuvolin ()
Tonofolin ()
Folinic acid calcium salt pentahydrate ()
Leucovorin calcium preservative free ()
Lederfolat ()
NSC-3590 ()
Folinate-Sf Calcium ()
Folaren ()
Calc Folinate ()
Lederfolin ()
Folic acid related compound a ()
Leucosar ()
Folinic Acid ()
Foliben ()
Fusilev ()
Folacal ()
[3H]folinic acid ()
Oncofolic ()
Leucovorin sodium ()
Folinic acid disodium ()
Disodium folinate ()
DL-Folinic Acid (calcium salt) ()
P&D ID
PD013847
CAS
1492-18-8
121521-95-7
6035-45-6
58-05-9
Tags
drug candidate
natural product
drug
available
Approved by
PMDA
FDA
First approval
1952
Drug Status
investigational
approved
Drug indication
Discovery agent
Colorectal cancer
Antidote (to folic acid antagonists)
Anti-Anemic (folate deficiency)
Solid tumour/cancer
Max Phase
Phase 4
Phase 3
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Folinic acid is the biologically active form of folic acid (also known as the (-)-l-isomer, citrovorum factor or (-)-folinic acid). The approved drug is called leucovorin. (GtoPdb)
DESCRIPTION Location of tritium is unknown. (GtoPdb)
DESCRIPTION Leucovorin is a derivative of folic acid, which can be used to increase levels of folic acid under conditions favoring folic acid inhibition. (BOC Sciences Bioactive Compounds)
Cell lines
1
Organisms
0
Compound Sets
27
AdooQ Bioactive Compound Library
A11110
BOC Sciences Bioactive Compounds
leucovorin-calcium-pentahydrate-cas-6035-45-6-345964
Cayman Chemical Bioactives
20383
ChEMBL Approved Drugs
CHEMBL1201138
CHEMBL1679
ChEMBL Drugs
CHEMBL1201138
CHEMBL1679
CHEMBL3707260
Concise Guide to Pharmacology 2017/18
4816
6690
Concise Guide to Pharmacology 2019/20
4816
6690
Concise Guide to Pharmacology 2021/22
4816
6690
Concise Guide to Pharmacology 2023/24
4816
6690
DrugBank
DB00650
DrugBank Approved Drugs
DB00650
DrugCentral
1232
DrugCentral Approved Drugs
1232
DrugMAP
DMNWZJG
DME0XHN
DMUAZWG
DrugMAP Approved Drugs
DMNWZJG
DMUAZWG
Enamine BioReference Compounds
Guide to Pharmacology
4816
6690
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL1679
MedChem Express Bioactive Compound Library
HY-13664
HY-B0080
HY-17556
NCATS Inxight Approved Drugs
Q573I9DVLP
NPC Screening Collection
Other bioactive compounds
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
calcium-folinate
Leucovorin-Calcium
folinic-acid
TargetMol Bioactive Compound Library
T0148
The Spectrum Collection
External IDs
129
Properties
(calculated by RDKit )
Molecular Weight
473.17
Hydrogen Bond Acceptors
9
Hydrogen Bond Donors
7
Rotatable Bonds
10
Ring Count
3
Aromatic Ring Count
2
cLogP
-0.73
TPSA
219.84
Fraction CSP3
0.3
Chiral centers
2.0
Largest ring
6.0
QED
0.21
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Antifolate
Thymidylate Synthase
VB
Folate Analogue
Endogenous Metabolite
DHFR
Pathway
Cell Cycle/DNA Damage
DNA Damage/DNA Repair
Metabolism
Metabolic Enzyme/Protease
MOA
DNA/RNA Synthesis inhibitor
Vitamin agonist
Therapeutic Class
Vitamins
Anticancer Agents
Source data