General
Preferred name
TRIPARANOL
Synonyms
Mer 2 ()
T-226293 ()
NSC-65345 ()
P&D ID
PD013837
CAS
78-41-1
Tags
available
drug
Drug indication
Obesity
Drug Status
approved
withdrawn
Max Phase
Phase 4
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Triparanol is a 24-dehydro cholesterol reductase (DHCR24) inhibitor with Ki value of 0.523 µM. It can be used as an antilipemic agent. It also exhibits anticancer activity that suppresses proliferation and induces apoptosis in many cancer cell lines. (BOC Sciences Bioactive Compounds)
Cell lines
1
Organisms
1
Compound Sets
11
BOC Sciences Bioactive Compounds
triparanol-cas-78-41-1-item-122035
Cayman Chemical Bioactives
20918
ChEMBL Approved Drugs
CHEMBL187709
ChEMBL Drugs
CHEMBL187709
DrugCentral
2761
DrugCentral Approved Drugs
2761
DrugMAP
DM7Y4GT
DrugMatrix
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL187709
NPC Screening Collection
Withdrawn 2.0
w134
External IDs
21
Properties
(calculated by RDKit )
Molecular Weight
437.21
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
1
Rotatable Bonds
10
Ring Count
3
Aromatic Ring Count
3
cLogP
5.85
TPSA
32.7
Fraction CSP3
0.33
Chiral centers
1.0
Largest ring
6.0
QED
0.43
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
ATC
C
Toxicity type
opthalmic
Source data