General
Preferred name
TALIPEXOLE
Synonyms
4H-thiazolo(4,5-d)azepin-2-amine, 5,6,7,8-tetrahydro-6-(2-propenyl)-, dihydrochloride ()
B-HT 920 ()
B-HT 920 dihydrochloride ()
Talipexole (dihydrochloride) ()
B-HT 920 (dihydrochloride) ()
B-HT 920 (hydrochloride) ()
P&D ID
PD013815
CAS
36085-73-1
101626-70-4
Tags
available
drug
Approved by
PMDA
Drug Status
approved
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Selective beta3 antagonist
(Tocris Bioactive Compound Library)
DESCRIPTION
Talipexole (B-HT920) is a highly selective agonist of D2 receptor and α2-adrenoceptor which has better ameliorative rate of symptom than bromocriptine and might be effctive in the treatment of Parkinson's disease.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
1
Compound Sets
15
Axon Medchem Screening Library
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
ChEMBL Drugs
Drug Repurposing Hub
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMatrix
Guide to Pharmacology
Ki Database
MedChem Express Bioactive Compound Library
NPC Screening Collection
ReFrame library
Tocris Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
40
Molecular Weight
209.1
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
1
Rotatable Bonds
2
Ring Count
2
Aromatic Ring Count
1
cLogP
1.31
TPSA
42.15
Fraction CSP3
0.5
Chiral centers
0.0
Largest ring
7.0
QED
0.75
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Dopamine Receptor
ADRA2A, DRD2, HTR3A
a2 and D2 agonist
5-HT Receptor
Adrenergic Receptor
Pathway
GPCR/G protein
Neuronal Signaling
Primary Target
D2 Receptors
MOA
Agonist
adrenergic receptor agonist, dopamine receptor agonist
Indication
genitial herpes
Solubility
10 mM in DMSO
Source data
